Cell atlas - NUDT9 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	NUDT9
Gene description	Nudix (nucleoside diphosphate linked moiety X)-type motif 9
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear membrane & mitochondria. In addition localized to the cell junctions.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear membrane (approved), Mitochondria (supported)
Additional location	In addition localized to the Cell Junctions (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA078535
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear membrane & mitochondria. In addition localized to the cell junctions.

Main location

Nuclear membrane (approved), Mitochondria (supported)

Additional location

Cell Junctions (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA078535	A549	Nuclear membrane
		Cell Junctions
		Mitochondria

GENE INFORMATION
Gene name	NUDT9 (HGNC Symbol)
Synonyms	MGC3037
Description	Nudix (nucleoside diphosphate linked moiety X)-type motif 9 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the Nudix hydrolase family. Nudix boxes are found in a family of diverse enzymes that catalyze the hydrolysis of nucleoside diphosphate derivatives. This enzyme is an ADP-ribose pyrophosphatase that catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. It requires divalent metal ions and an intact Nudix motif for enzymatic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Chromosome	4
Cytoband	q22.1
Chromosome location (bp)	87422582 - 87459454
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170502 (version 83.38)
Entrez gene	53343
UniProt	Q9BW91 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BW91
Antibodypedia	NUDT9 antibodies

PROTEIN BROWSER

NUDT9-001	NUDT9-002	NUDT9-003	NUDT9-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NUDT9-001 ENSP00000303575 ENST00000302174	Q9BW91 [Direct mapping] ADP-ribose pyrophosphatase, mitochondrial A0A024RDI6 [Target identity:100%; Query identity:100%] Nudix (Nucleoside diphosphate linked moiety X)-type motif 9, isoform CRA_b Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0005759 [mitochondrial matrix] GO:0016787 [hydrolase activity] GO:0019144 [ADP-sugar diphosphatase activity] GO:0034656 [nucleobase-containing small molecule catabolic process] GO:0043262 [adenosine-diphosphatase activity] GO:0044281 [small molecule metabolic process] GO:0046032 [ADP catabolic process] GO:0046709 [IDP catabolic process] GO:0047631 [ADP-ribose diphosphatase activity] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	350 aa 39.1 kDa	Yes	0
NUDT9-002 ENSP00000421811 ENST00000473942	Q9BW91 [Direct mapping] ADP-ribose pyrophosphatase, mitochondrial Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0005759 [mitochondrial matrix] GO:0016787 [hydrolase activity] GO:0019144 [ADP-sugar diphosphatase activity] GO:0034656 [nucleobase-containing small molecule catabolic process] GO:0044281 [small molecule metabolic process] GO:0047631 [ADP-ribose diphosphatase activity] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	300 aa 33.8 kDa	No	0
NUDT9-003 ENSP00000410270 ENST00000440591	H7C386 [Direct mapping] ADP-ribose pyrophosphatase, mitochondrial Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	284 aa 31.5 kDa	Yes	0
NUDT9-004 ENSP00000424702 ENST00000512216	D6RAW2 [Direct mapping] ADP-ribose pyrophosphatase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	206 aa 23 kDa	No	0