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PFKFB3

GENERAL INFORMATION

Gene name

 PFKFB3

Gene description

 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in mosttissues.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
CAB020795
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PFKFB3

Synonyms

Description

 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2015]

Chromosome

 10

Cytoband

 p15.1

Chromosome location (bp)

 6144934 - 6235545

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170525 (version 83.38)

Entrez gene

 5209

UniProt

 Q16875 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16875

Antibodypedia

 PFKFB3 antibodies

PROTEIN BROWSER
«
PFKFB3-001
PFKFB3-002
PFKFB3-005
PFKFB3-006
PFKFB3-010
PFKFB3-011
PFKFB3-013
PFKFB3-015
PFKFB3-201
PFKFB3-202
PFKFB3-203
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PFKFB3-001
ENSP00000369115
ENST00000379789
Q16875 [Direct mapping]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 6-phosphofructo-2-kinase Fructose-2,6-bisphosphatase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003873 [6-phosphofructo-2-kinase activity]
GO:0004331 [fructose-2,6-bisphosphate 2-phosphatase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006000 [fructose metabolic process]
GO:0006006 [glucose metabolic process]
GO:0008152 [metabolic process]
GO:0016311 [dephosphorylation]
GO:0044281 [small molecule metabolic process]
GO:0046835 [carbohydrate phosphorylation]
GO:0061621 [canonical glycolysis]
Show all
 500 aa
57.3 kDa 		No 0
PFKFB3-002
ENSP00000369100
ENST00000379775
Q16875 [Direct mapping]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 6-phosphofructo-2-kinase Fructose-2,6-bisphosphatase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003873 [6-phosphofructo-2-kinase activity]
GO:0004331 [fructose-2,6-bisphosphate 2-phosphatase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006000 [fructose metabolic process]
GO:0006006 [glucose metabolic process]
GO:0008152 [metabolic process]
GO:0016311 [dephosphorylation]
GO:0044281 [small molecule metabolic process]
GO:0046835 [carbohydrate phosphorylation]
GO:0061621 [canonical glycolysis]
Show all
 520 aa
59.6 kDa 		No 0
PFKFB3-005
ENSP00000416677
ENST00000414237
Q9H178 [Direct mapping]
6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003873 [6-phosphofructo-2-kinase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0006003 [fructose 2,6-bisphosphate metabolic process]
GO:0046835 [carbohydrate phosphorylation]
Show all
 92 aa
10 kDa 		No 0
PFKFB3-006
ENSP00000353712
ENST00000360521
Q16875 [Direct mapping]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 6-phosphofructo-2-kinase Fructose-2,6-bisphosphatase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003873 [6-phosphofructo-2-kinase activity]
GO:0004331 [fructose-2,6-bisphosphate 2-phosphatase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006000 [fructose metabolic process]
GO:0006006 [glucose metabolic process]
GO:0008152 [metabolic process]
GO:0016311 [dephosphorylation]
GO:0044281 [small molecule metabolic process]
GO:0046835 [carbohydrate phosphorylation]
GO:0061621 [canonical glycolysis]
Show all
 514 aa
58.9 kDa 		No 0
PFKFB3-010
ENSP00000369111
ENST00000379785
Q5VX20 [Direct mapping]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003873 [6-phosphofructo-2-kinase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0006000 [fructose metabolic process]
GO:0006003 [fructose 2,6-bisphosphate metabolic process]
GO:0008152 [metabolic process]
GO:0046835 [carbohydrate phosphorylation]
Show all
 526 aa
60.3 kDa 		No 0
PFKFB3-011
ENSP00000404995
ENST00000441697
Q9BQU1 [Direct mapping]
6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003873 [6-phosphofructo-2-kinase activity]
GO:0046835 [carbohydrate phosphorylation]
Show all
 31 aa
3.6 kDa 		No 0
PFKFB3-013
ENSP00000390285
ENST00000450232
H0Y483 [Direct mapping]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005524 [ATP binding]
GO:0006003 [fructose 2,6-bisphosphate metabolic process]
Show all
 143 aa
16.5 kDa 		No 0
PFKFB3-015
ENSP00000369105
ENST00000317350
Q5W015 [Direct mapping]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003873 [6-phosphofructo-2-kinase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0006000 [fructose metabolic process]
GO:0006003 [fructose 2,6-bisphosphate metabolic process]
GO:0008152 [metabolic process]
GO:0046835 [carbohydrate phosphorylation]
Show all
 513 aa
58.8 kDa 		No 0
PFKFB3-201
ENSP00000443319
ENST00000536985
Q16875 [Direct mapping]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 6-phosphofructo-2-kinase Fructose-2,6-bisphosphatase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003873 [6-phosphofructo-2-kinase activity]
GO:0004331 [fructose-2,6-bisphosphate 2-phosphatase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006000 [fructose metabolic process]
GO:0006003 [fructose 2,6-bisphosphate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0007420 [brain development]
GO:0008152 [metabolic process]
GO:0016311 [dephosphorylation]
GO:0044281 [small molecule metabolic process]
GO:0046835 [carbohydrate phosphorylation]
GO:0061621 [canonical glycolysis]
Show all
 534 aa
60.6 kDa 		No 0
PFKFB3-202
ENSP00000486311
ENST00000625260
F2Z2I2 [Direct mapping]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003873 [6-phosphofructo-2-kinase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0006000 [fructose metabolic process]
GO:0006003 [fructose 2,6-bisphosphate metabolic process]
GO:0008152 [metabolic process]
GO:0046835 [carbohydrate phosphorylation]
Show all
 455 aa
52.6 kDa 		No 0
PFKFB3-203
ENSP00000487277
ENST00000626882
Q5VX20 [Direct mapping]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003873 [6-phosphofructo-2-kinase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0006000 [fructose metabolic process]
GO:0006003 [fructose 2,6-bisphosphate metabolic process]
GO:0008152 [metabolic process]
GO:0046835 [carbohydrate phosphorylation]
Show all
 526 aa
60.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.