Expression of SERPINB9 in cancer - Summary

CANCER ATLAS

Gene description

Serpin peptidase inhibitor, clade B (ovalbumin), member 9

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Melanoma

STAINING SUMMARY

HPA030067

GENE INFORMATION
Gene name	SERPINB9 (HGNC Symbol)
Synonyms	CAP3, PI9
Description	Serpin peptidase inhibitor, clade B (ovalbumin), member 9 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the serine protease inhibitor family which are also known as serpins. The encoded protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2012]
Chromosome	6
Cytoband	p25.2
Chromosome location (bp)	2887266 - 2903280
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170542 (version 83.38)
Entrez gene	5272
UniProt	P50453 (UniProt - Evidence at protein level)
neXtProt	NX_P50453
Antibodypedia	SERPINB9 antibodies

PROTEIN BROWSER

SERPINB9-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SERPINB9-001 ENSP00000370074 ENST00000380698	P50453 [Direct mapping] Serpin B9 A0A024QZT4 [Target identity:100%; Query identity:100%] Serpin peptidase inhibitor, clade B (Ovalbumin), member 9, isoform CRA_a Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0002448 [mast cell mediated immunity] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006915 [apoptotic process] GO:0006955 [immune response] GO:0009617 [response to bacterium] GO:0010628 [positive regulation of gene expression] GO:0010951 [negative regulation of endopeptidase activity] GO:0016020 [membrane] GO:0033668 [negative regulation by symbiont of host apoptotic process] GO:0042270 [protection from natural killer cell mediated cytotoxicity] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0070062 [extracellular exosome] GO:0071391 [cellular response to estrogen stimulus] Show all	376 aa 42.4 kDa	No	0