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SERPINB9

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GENERAL INFORMATION

Gene name

 SERPINB9

Gene description

 Serpin peptidase inhibitor, clade B (ovalbumin), member 9

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (BEWO, U-698)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BEWO, U-698)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 SERPINB9 (HGNC Symbol)

Synonyms

 CAP3, PI9

Description

 Serpin peptidase inhibitor, clade B (ovalbumin), member 9 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the serine protease inhibitor family which are also known as serpins. The encoded protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2012]

Chromosome

 6

Cytoband

 p25.2

Chromosome location (bp)

 2887266 - 2903280

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170542 (version 83.38)

Entrez gene

 5272

UniProt

 P50453 (UniProt - Evidence at protein level)

neXtProt

 NX_P50453

Antibodypedia

 SERPINB9 antibodies

PROTEIN BROWSER
SERPINB9-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SERPINB9-001
ENSP00000370074
ENST00000380698
P50453 [Direct mapping]
Serpin B9
A0A024QZT4 [Target identity:100%; Query identity:100%]
Serpin peptidase inhibitor, clade B (Ovalbumin), member 9, isoform CRA_a
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0002448 [mast cell mediated immunity]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006955 [immune response]
GO:0009617 [response to bacterium]
GO:0010628 [positive regulation of gene expression]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0016020 [membrane]
GO:0033668 [negative regulation by symbiont of host apoptotic process]
GO:0042270 [protection from natural killer cell mediated cytotoxicity]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0070062 [extracellular exosome]
GO:0071391 [cellular response to estrogen stimulus]
Show all
 376 aa
42.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.