Cell atlas - HOXB9 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

HOXB9

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria
	Nucleoplasm

Human cell
	Mitochondria
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	HOXB9
Gene description	Homeobox B9
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria & nucleoplasm.
RNA cell category	Cell line enhanced (HDLM-2, K-562, HEK 293, HMC-1)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Mitochondria (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA031463
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HDLM-2, K-562, HEK 293, HMC-1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria & nucleoplasm.

Main location

Nucleoplasm (approved), Mitochondria (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA031463	A-431	Nucleoplasm
	HPA031463	A-431	Mitochondria	Intensity
	HPA031463	U-2 OS	Nucleoplasm
	HPA031463	U-2 OS	Mitochondria
	HPA031463	U-251 MG	Nucleoplasm
	HPA031463	U-251 MG	Mitochondria

GENE INFORMATION
Gene name	HOXB9 (HGNC Symbol)
Synonyms	HOX2, HOX2E
Description	Homeobox B9 (HGNC Symbol)
Entrez gene summary	This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.32
Chromosome location (bp)	48621159 - 48626356
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170689 (version 83.38)
Entrez gene	3219
UniProt	P17482 (UniProt - Evidence at protein level)
neXtProt	NX_P17482
Antibodypedia	HOXB9 antibodies

PROTEIN BROWSER

HOXB9-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HOXB9-001 ENSP00000309439 ENST00000311177	P17482 [Direct mapping] Homeobox protein Hox-B9 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0009952 [anterior/posterior pattern specification] GO:0030879 [mammary gland development] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048706 [embryonic skeletal system development] GO:0060070 [canonical Wnt signaling pathway] GO:0060326 [cell chemotaxis] Show all	250 aa 28.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.