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TRH

CANCER ATLAS

Gene description

 Thyrotropin-releasing hormone

Protein class

 Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035595
HPA035596

GENE INFORMATION

Gene name

 TRH

Synonyms

Description

 Thyrotropin-releasing hormone (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The human proprotein contains six thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism. [provided by RefSeq, May 2013]

Chromosome

 3

Cytoband

 q22.1

Chromosome location (bp)

 129974305 - 129977938

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170893 (version 83.38)

Entrez gene

 7200

UniProt

 P20396 (UniProt - Evidence at protein level)

neXtProt

 NX_P20396

Antibodypedia

 TRH antibodies

PROTEIN BROWSER
TRH-001
TRH-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRH-001
ENSP00000303452
ENST00000302649
P20396 [Direct mapping]
Pro-thyrotropin-releasing hormone Thyrotropin-releasing hormone
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001692 [histamine metabolic process]
GO:0005184 [neuropeptide hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007628 [adult walking behavior]
GO:0008437 [thyrotropin-releasing hormone activity]
GO:0009409 [response to cold]
GO:0009749 [response to glucose]
GO:0009755 [hormone-mediated signaling pathway]
GO:0014050 [negative regulation of glutamate secretion]
GO:0014054 [positive regulation of gamma-aminobutyric acid secretion]
GO:0014070 [response to organic cyclic compound]
GO:0030141 [secretory granule]
GO:0032024 [positive regulation of insulin secretion]
GO:0042755 [eating behavior]
GO:0045471 [response to ethanol]
GO:0051412 [response to corticosterone]
GO:2000252 [negative regulation of feeding behavior]
Show all
 242 aa
27.4 kDa 		Yes 0
TRH-002
ENSP00000426522
ENST00000507066
D6RFM1 [Direct mapping]
Pro-thyrotropin-releasing hormone
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005184 [neuropeptide hormone activity]
GO:0005576 [extracellular region]
GO:0009755 [hormone-mediated signaling pathway]
Show all
 238 aa
27 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.