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TRH

GENERAL INFORMATION

Gene name

 TRH

Gene description

 Thyrotropin-releasing hormone

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (cervix, uterine, endometrium)
GTEx:Tissue enriched (hypothalamus)
FANTOM5:Tissue enhanced (cervix, uterine, endometrium, retina)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic and membranous expression in glandular cells of uterus.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA035595 , HPA035596
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Hypothalamus

Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cervix, uterine, endometrium)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cervix, uterine, endometrium, retina)

GENE INFORMATION

Gene name

 TRH

Synonyms

Description

 Thyrotropin-releasing hormone (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The human proprotein contains six thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism. [provided by RefSeq, May 2013]

Chromosome

 3

Cytoband

 q22.1

Chromosome location (bp)

 129974305 - 129977938

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170893 (version 83.38)

Entrez gene

 7200

UniProt

 P20396 (UniProt - Evidence at protein level)

neXtProt

 NX_P20396

Antibodypedia

 TRH antibodies

PROTEIN BROWSER
TRH-001
TRH-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRH-001
ENSP00000303452
ENST00000302649
P20396 [Direct mapping]
Pro-thyrotropin-releasing hormone Thyrotropin-releasing hormone
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0001666 [response to hypoxia]
GO:0001692 [histamine metabolic process]
GO:0005184 [neuropeptide hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007628 [adult walking behavior]
GO:0008437 [thyrotropin-releasing hormone activity]
GO:0009409 [response to cold]
GO:0009749 [response to glucose]
GO:0009755 [hormone-mediated signaling pathway]
GO:0014050 [negative regulation of glutamate secretion]
GO:0014054 [positive regulation of gamma-aminobutyric acid secretion]
GO:0014070 [response to organic cyclic compound]
GO:0030141 [secretory granule]
GO:0032024 [positive regulation of insulin secretion]
GO:0042755 [eating behavior]
GO:0045471 [response to ethanol]
GO:0051412 [response to corticosterone]
GO:2000252 [negative regulation of feeding behavior]
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 242 aa
27.4 kDa 		Yes 0
TRH-002
ENSP00000426522
ENST00000507066
D6RFM1 [Direct mapping]
Pro-thyrotropin-releasing hormone
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005184 [neuropeptide hormone activity]
GO:0005576 [extracellular region]
GO:0009755 [hormone-mediated signaling pathway]
Show all
 238 aa
27 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.