Expression of MBD3L1 in cancer - Summary

CANCER ATLAS

Gene description

Methyl-CpG binding domain protein 3-like 1

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Testis cancer

STAINING SUMMARY

HPA043121	HPA046753

GENE INFORMATION
Gene name	MBD3L1 (HGNC Symbol)
Synonyms	MBD3L
Description	Methyl-CpG binding domain protein 3-like 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is related to methyl-CpG-binding proteins but lacks the methyl-CpG binding domain. The protein is localized to discrete areas in the nucleus, and expression appears to be restricted to round spermatids, suggesting that the protein plays a role in the postmeiotic stages of male germ cell development. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	8832398 - 8843340
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170948 (version 83.38)
Entrez gene	85509
UniProt	Q8WWY6 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8WWY6
Antibodypedia	MBD3L1 antibodies

PROTEIN BROWSER

MBD3L1-001	MBD3L1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MBD3L1-001 ENSP00000471575 ENST00000595891	Q8WWY6 [Direct mapping] Methyl-CpG-binding domain protein 3-like 1 Show all	Predicted intracellular proteins Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006346 [methylation-dependent chromatin silencing] GO:0006351 [transcription, DNA-templated] GO:0008327 [methyl-CpG binding] Show all	194 aa 21.6 kDa	No	0
MBD3L1-002 ENSP00000304198 ENST00000305625	Q8WWY6 [Direct mapping] Methyl-CpG-binding domain protein 3-like 1 Show all	Predicted intracellular proteins Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006346 [methylation-dependent chromatin silencing] GO:0006351 [transcription, DNA-templated] GO:0008327 [methyl-CpG binding] Show all	194 aa 21.6 kDa	No	0