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MBD3L1

GENERAL INFORMATION

Gene name

 MBD3L1

Gene description

 Methyl-CpG binding domain protein 3-like 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (testis)
GTEx:Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in subsets of cells in testis and fallopian tube.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 2 antibodies.
HPA043121 , HPA046753
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Fallopian tube

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)

GENE INFORMATION

Gene name

 MBD3L1 (HGNC Symbol)

Synonyms

 MBD3L

Description

 Methyl-CpG binding domain protein 3-like 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that is related to methyl-CpG-binding proteins but lacks the methyl-CpG binding domain. The protein is localized to discrete areas in the nucleus, and expression appears to be restricted to round spermatids, suggesting that the protein plays a role in the postmeiotic stages of male germ cell development. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.2

Chromosome location (bp)

 8832398 - 8843340

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170948 (version 83.38)

Entrez gene

 85509

UniProt

 Q8WWY6 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q8WWY6

Antibodypedia

 MBD3L1 antibodies

PROTEIN BROWSER
MBD3L1-001
MBD3L1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MBD3L1-001
ENSP00000471575
ENST00000595891
Q8WWY6 [Direct mapping]
Methyl-CpG-binding domain protein 3-like 1
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Predicted intracellular proteins
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006346 [methylation-dependent chromatin silencing]
GO:0006351 [transcription, DNA-templated]
GO:0008327 [methyl-CpG binding]
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 194 aa
21.6 kDa 		No 0
MBD3L1-002
ENSP00000304198
ENST00000305625
Q8WWY6 [Direct mapping]
Methyl-CpG-binding domain protein 3-like 1
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Predicted intracellular proteins
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006346 [methylation-dependent chromatin silencing]
GO:0006351 [transcription, DNA-templated]
GO:0008327 [methyl-CpG binding]
Show all
 194 aa
21.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.