Cell atlas - PRKCDBP - The Human Protein Atlas

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PRKCDBP

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Plasma membrane

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	PRKCDBP
Gene description	Protein kinase C, delta binding protein
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane.
RNA cell category	Cell line enhanced (WM-115, U-87 MG, TIME, A-431, BJ)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA073327
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (WM-115, U-87 MG, TIME, A-431, BJ) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane.

Main location

Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA073327	A-431	Plasma membrane
	HPA073327	HaCaT	Plasma membrane

GENE INFORMATION
Gene name	PRKCDBP (HGNC Symbol)
Synonyms	cavin-3, CAVIN3, HSRBC, MGC20400, SRBC
Description	Protein kinase C, delta binding protein (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene was identified as a binding protein of the protein kinase C, delta (PRKCD). The expression of this gene in cultured cell lines is strongly induced by serum starvation. The expression of this protein was found to be down-regulated in various cancer cell lines, suggesting the possible tumor suppressor function of this protein. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	p15.4
Chromosome location (bp)	6318946 - 6320647
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170955 (version 83.38)
Entrez gene	112464
UniProt	Q969G5 (UniProt - Evidence at protein level)
neXtProt	NX_Q969G5
Antibodypedia	PRKCDBP antibodies

PROTEIN BROWSER

PRKCDBP-001	PRKCDBP-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRKCDBP-001 ENSP00000307292 ENST00000303927	Q969G5 [Direct mapping] Protein kinase C delta-binding protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005080 [protein kinase C binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005901 [caveola] GO:0030866 [cortical actin cytoskeleton organization] GO:0032922 [circadian regulation of gene expression] GO:0043234 [protein complex] GO:0051898 [negative regulation of protein kinase B signaling] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:1901003 [negative regulation of fermentation] Show all	261 aa 27.7 kDa	No	0
PRKCDBP-004 ENSP00000432047 ENST00000530979	E9PIE3 [Direct mapping] Protein kinase C delta-binding protein Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005080 [protein kinase C binding] GO:0005737 [cytoplasm] Show all	293 aa 31.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.