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CCBL1

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GENERAL INFORMATION

Gene name

 CCBL1

Gene description

 Cysteine conjugate-beta lyase, cytoplasmic

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol. In addition localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (validated)

Additional location

 In addition localized to the Nucleoplasm (validated)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA021176 , HPA021177
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol. In addition localized to the nucleoplasm.

Main location

 Cytosol (validated)

Additional location

 Nucleoplasm (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA021176 A-431 Nucleoplasm
Cytosol
HPA021176 U-2 OS Cytosol
HPA021176 U-251 MG Cytosol
HPA021177 A-431 Cytosol
HPA021177 U-2 OS Cytosol

GENE INFORMATION

Gene name

 CCBL1 (HGNC Symbol)

Synonyms

 GTK, KATI

Description

 Cysteine conjugate-beta lyase, cytoplasmic (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q34.11

Chromosome location (bp)

 128832942 - 128882494

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171097 (version 83.38)

Entrez gene

 883

UniProt

 Q16773 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16773

Antibodypedia

 CCBL1 antibodies

PROTEIN BROWSER
CCBL1-001
CCBL1-002
CCBL1-005
CCBL1-007
CCBL1-009
CCBL1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCBL1-001
ENSP00000302227
ENST00000302586
Q16773 [Direct mapping]
Kynurenine--oxoglutarate transaminase 1
A8K563 [Target identity:100%; Query identity:100%]
Cysteine conjugate-beta lyase cytoplasmic (Glutamine transaminase K, kyneurenine aminotransferase), isoform CRA_a; cDNA FLJ77833, highly similar to H.sapiens glutamine transaminase K; cDNA, FLJ95217, Homo sapiens cysteine conjugate-beta lyase; cytoplasmic (glutaminetransaminase K, kyneurenine aminotransferase) (CCBL1), mRNA
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Enzymes
   ENZYME proteins
   Transferases
   Lyases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006559 [L-phenylalanine catabolic process]
GO:0006569 [tryptophan catabolic process]
GO:0006575 [cellular modified amino acid metabolic process]
GO:0008483 [transaminase activity]
GO:0008652 [cellular amino acid biosynthetic process]
GO:0009058 [biosynthetic process]
GO:0016212 [kynurenine-oxoglutarate transaminase activity]
GO:0030170 [pyridoxal phosphate binding]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0047312 [L-phenylalanine:pyruvate aminotransferase activity]
GO:0047316 [glutamine-phenylpyruvate transaminase activity]
GO:0047804 [cysteine-S-conjugate beta-lyase activity]
GO:0047945 [L-glutamine:pyruvate aminotransferase activity]
GO:0070189 [kynurenine metabolic process]
GO:0097053 [L-kynurenine catabolic process]
Show all
 422 aa
47.9 kDa 		No 0
CCBL1-002
ENSP00000317342
ENST00000320665
Q16773 [Direct mapping]
Kynurenine--oxoglutarate transaminase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Lyases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006559 [L-phenylalanine catabolic process]
GO:0006569 [tryptophan catabolic process]
GO:0006575 [cellular modified amino acid metabolic process]
GO:0008483 [transaminase activity]
GO:0008652 [cellular amino acid biosynthetic process]
GO:0009058 [biosynthetic process]
GO:0016212 [kynurenine-oxoglutarate transaminase activity]
GO:0030170 [pyridoxal phosphate binding]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0047312 [L-phenylalanine:pyruvate aminotransferase activity]
GO:0047316 [glutamine-phenylpyruvate transaminase activity]
GO:0047804 [cysteine-S-conjugate beta-lyase activity]
GO:0047945 [L-glutamine:pyruvate aminotransferase activity]
GO:0070189 [kynurenine metabolic process]
GO:0097053 [L-kynurenine catabolic process]
Show all
 372 aa
42.5 kDa 		No 0
CCBL1-005
ENSP00000390377
ENST00000451800
Q5T278 [Direct mapping]
Kynurenine--oxoglutarate transaminase 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005737 [cytoplasm]
GO:0009058 [biosynthetic process]
GO:0030170 [pyridoxal phosphate binding]
Show all
 251 aa
27.8 kDa 		No 0
CCBL1-007
ENSP00000412402
ENST00000416084
Q5T276 [Direct mapping]
Kynurenine--oxoglutarate transaminase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005737 [cytoplasm]
GO:0009058 [biosynthetic process]
GO:0030170 [pyridoxal phosphate binding]
Show all
 184 aa
20.3 kDa 		No 0
CCBL1-009
ENSP00000392354
ENST00000427720
Q5T277 [Direct mapping]
Kynurenine--oxoglutarate transaminase 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 159 aa
17.5 kDa 		No 0
CCBL1-201
ENSP00000399415
ENST00000436267
B7Z4W5 [Direct mapping]
Cysteine conjugate-beta lyase cytoplasmic (Glutamine transaminase K, kyneurenine aminotransferase), isoform CRA_b; Kynurenine--oxoglutarate transaminase 1; cDNA FLJ56468, highly similar to Kynurenine--oxoglutarate transaminase 1 (EC 2.6.1.7)
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006090 [pyruvate metabolic process]
GO:0009058 [biosynthetic process]
GO:0030170 [pyridoxal phosphate binding]
GO:0047316 [glutamine-phenylpyruvate transaminase activity]
GO:0047804 [cysteine-S-conjugate beta-lyase activity]
GO:0097052 [L-kynurenine metabolic process]
Show all
 516 aa
57.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.