Expression of MFN1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Mitofusin 1

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB033437

GENE INFORMATION
Gene name	MFN1 (HGNC Symbol)
Synonyms	FLJ20693
Description	Mitofusin 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q26.33
Chromosome location (bp)	179347692 - 179394931
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171109 (version 83.38)
Entrez gene	55669
UniProt
neXtProt
Antibodypedia	MFN1 antibodies

PROTEIN BROWSER

MFN1-001	MFN1-003	MFN1-004	MFN1-005	MFN1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MFN1-001 ENSP00000420617 ENST00000471841	A0A0C4DFN1 [Direct mapping] Mitofusin-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005741 [mitochondrial outer membrane] GO:0008053 [mitochondrial fusion] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] Show all	741 aa 84.2 kDa	No	4
MFN1-003 ENSP00000263969 ENST00000263969	A0A0C4DFN1 [Direct mapping] Mitofusin-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005525 [GTP binding] GO:0005741 [mitochondrial outer membrane] GO:0008053 [mitochondrial fusion] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] Show all	741 aa 84.2 kDa	No	4
MFN1-004 ENSP00000419926 ENST00000474903	H7C5H5 [Direct mapping] Mitofusin-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005525 [GTP binding] GO:0005741 [mitochondrial outer membrane] GO:0008053 [mitochondrial fusion] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] Show all	493 aa 56.2 kDa	No	4
MFN1-005 ENSP00000419134 ENST00000467174	C9JXQ1 [Direct mapping] Mitofusin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005525 [GTP binding] GO:0005741 [mitochondrial outer membrane] GO:0008053 [mitochondrial fusion] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] Show all	155 aa 17.1 kDa	No	0
MFN1-006 ENSP00000420148 ENST00000489329	C9JQT7 [Direct mapping] Mitofusin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005525 [GTP binding] GO:0005741 [mitochondrial outer membrane] GO:0008053 [mitochondrial fusion] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] Show all	124 aa 14.4 kDa	No	0