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MFN1

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GENERAL INFORMATION

Gene name

 MFN1

Gene description

 Mitofusin 1

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the mitochondria.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Mitochondria (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA059230
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the mitochondria.

Main location

 Mitochondria (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA059230 U-2 OS Mitochondria
HPA059230 U-251 MG No staining    

GENE INFORMATION

Gene name

 MFN1 (HGNC Symbol)

Synonyms

 FLJ20693

Description

 Mitofusin 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q26.33

Chromosome location (bp)

 179347692 - 179394931

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171109 (version 83.38)

Entrez gene

 55669

UniProt

neXtProt

Antibodypedia

 MFN1 antibodies

PROTEIN BROWSER
MFN1-001
MFN1-003
MFN1-004
MFN1-005
MFN1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MFN1-001
ENSP00000420617
ENST00000471841
A0A0C4DFN1 [Direct mapping]
Mitofusin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005741 [mitochondrial outer membrane]
GO:0008053 [mitochondrial fusion]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
Show all
 741 aa
84.2 kDa 		No 4
MFN1-003
ENSP00000263969
ENST00000263969
A0A0C4DFN1 [Direct mapping]
Mitofusin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005741 [mitochondrial outer membrane]
GO:0008053 [mitochondrial fusion]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
Show all
 741 aa
84.2 kDa 		No 4
MFN1-004
ENSP00000419926
ENST00000474903
H7C5H5 [Direct mapping]
Mitofusin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005741 [mitochondrial outer membrane]
GO:0008053 [mitochondrial fusion]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
Show all
 493 aa
56.2 kDa 		No 4
MFN1-005
ENSP00000419134
ENST00000467174
C9JXQ1 [Direct mapping]
Mitofusin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005741 [mitochondrial outer membrane]
GO:0008053 [mitochondrial fusion]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
Show all
 155 aa
17.1 kDa 		No 0
MFN1-006
ENSP00000420148
ENST00000489329
C9JQT7 [Direct mapping]
Mitofusin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005741 [mitochondrial outer membrane]
GO:0008053 [mitochondrial fusion]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
Show all
 124 aa
14.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.