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Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008]
Q02156 [Direct mapping] Protein kinase C epsilon type L7RTI5 [Target identity:100%; Query identity:100%] Protein kinase C epsilon type
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Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002281 [macrophage activation involved in immune response] GO:0003785 [actin monomer binding] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004697 [protein kinase C activity] GO:0004699 [calcium-independent protein kinase C activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007049 [cell cycle] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007596 [blood coagulation] GO:0008047 [enzyme activator activity] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010634 [positive regulation of epithelial cell migration] GO:0010763 [positive regulation of fibroblast migration] GO:0010811 [positive regulation of cell-substrate adhesion] GO:0016020 [membrane] GO:0018105 [peptidyl-serine phosphorylation] GO:0019216 [regulation of lipid metabolic process] GO:0019899 [enzyme binding] GO:0030168 [platelet activation] GO:0030546 [receptor activator activity] GO:0030838 [positive regulation of actin filament polymerization] GO:0031397 [negative regulation of protein ubiquitination] GO:0031663 [lipopolysaccharide-mediated signaling pathway] GO:0032024 [positive regulation of insulin secretion] GO:0032230 [positive regulation of synaptic transmission, GABAergic] GO:0032467 [positive regulation of cytokinesis] GO:0035276 [ethanol binding] GO:0035556 [intracellular signal transduction] GO:0035641 [locomotory exploration behavior] GO:0035669 [TRAM-dependent toll-like receptor 4 signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043278 [response to morphine] GO:0043410 [positive regulation of MAPK cascade] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0050730 [regulation of peptidyl-tyrosine phosphorylation] GO:0050996 [positive regulation of lipid catabolic process] GO:0051209 [release of sequestered calcium ion into cytosol] GO:0051279 [regulation of release of sequestered calcium ion into cytosol] GO:0051301 [cell division] GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0070257 [positive regulation of mucus secretion] GO:0071361 [cellular response to ethanol] GO:0071380 [cellular response to prostaglandin E stimulus] GO:0071456 [cellular response to hypoxia] GO:0071889 [14-3-3 protein binding] GO:0071944 [cell periphery] GO:0090303 [positive regulation of wound healing] GO:2000273 [positive regulation of receptor activity] GO:2000650 [negative regulation of sodium ion transmembrane transporter activity] GO:2001031 [positive regulation of cellular glucuronidation]