Cell atlas - LRG1 - The Human Protein Atlas

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LRG1

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	LRG1
Gene description	Leucine-rich alpha-2-glycoprotein 1
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Cell line enhanced (U-937, THP-1)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA001889
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-937, THP-1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA001889	Hep G2	Vesicles	Intensity

GENE INFORMATION
Gene name	LRG1 (HGNC Symbol)
Synonyms	LRG
Description	Leucine-rich alpha-2-glycoprotein 1 (HGNC Symbol)
Entrez gene summary	The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation (O'Donnell et al., 2002 [PubMed 12223515]).[supplied by OMIM, Mar 2008]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	4536409 - 4540474
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171236 (version 83.38)
Entrez gene	116844
UniProt	P02750 (UniProt - Evidence at protein level)
neXtProt	NX_P02750
Antibodypedia	LRG1 antibodies

PROTEIN BROWSER

LRG1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRG1-001 ENSP00000302621 ENST00000306390	P02750 [Direct mapping] Leucine-rich alpha-2-glycoprotein Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001938 [positive regulation of endothelial cell proliferation] GO:0003674 [molecular_function] GO:0005160 [transforming growth factor beta receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0008150 [biological_process] GO:0016020 [membrane] GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway] GO:0045766 [positive regulation of angiogenesis] GO:0050873 [brown fat cell differentiation] GO:0070062 [extracellular exosome] Show all	347 aa 38.2 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.