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KRT19

GENERAL INFORMATION

Gene name

 KRT19

Gene description

 Keratin 19, type I

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Tissue enhanced (small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in glandular, respiratory and squamous epithelium as well as renal tubules, exocrine pancreas and trophoblasts.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA002465 , CAB000031
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Breast

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine)

GENE INFORMATION

Gene name

 KRT19 (HGNC Symbol)

Synonyms

 CK19, K19, K1CS, MGC15366

Description

 Keratin 19, type I (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q21.2

Chromosome location (bp)

 41523617 - 41528308

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171345 (version 83.38)

Entrez gene

 3880

UniProt

 P08727 (UniProt - Evidence at protein level)

neXtProt

 NX_P08727

Antibodypedia

 KRT19 antibodies

PROTEIN BROWSER
KRT19-001
KRT19-002
KRT19-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KRT19-001
ENSP00000355124
ENST00000361566
P08727 [Direct mapping]
Keratin, type I cytoskeletal 19
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005882 [intermediate filament]
GO:0005886 [plasma membrane]
GO:0007219 [Notch signaling pathway]
GO:0008307 [structural constituent of muscle]
GO:0016010 [dystrophin-associated glycoprotein complex]
GO:0016032 [viral process]
GO:0030018 [Z disc]
GO:0032403 [protein complex binding]
GO:0042383 [sarcolemma]
GO:0043034 [costamere]
GO:0043627 [response to estrogen]
GO:0045214 [sarcomere organization]
GO:0060706 [cell differentiation involved in embryonic placenta development]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:1990357 [terminal web]
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 400 aa
44.1 kDa 		No 0
KRT19-002
ENSP00000408759
ENST00000455635
C9JM50 [Direct mapping]
Keratin, type I cytoskeletal 19
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
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 196 aa
20.8 kDa 		No 0
KRT19-007
ENSP00000466625
ENST00000593096
K7EMS3 [Direct mapping]
Keratin, type I cytoskeletal 19
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
Show all
 181 aa
20.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.