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TBCA

CANCER ATLAS

Gene description

 Tubulin folding cofactor A

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036487

GENE INFORMATION

Gene name

 TBCA

Synonyms

Description

 Tubulin folding cofactor A (HGNC Symbol)

Entrez gene summary

 The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Chromosome

 5

Cytoband

 q14.1

Chromosome location (bp)

 77691166 - 77868780

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171530 (version 83.38)

Entrez gene

 6902

UniProt

 O75347 (UniProt - Evidence at protein level)

neXtProt

 NX_O75347

Antibodypedia

 TBCA antibodies

PROTEIN BROWSER
TBCA-001
TBCA-002
TBCA-003
TBCA-004
TBCA-005
TBCA-006
TBCA-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TBCA-001
ENSP00000369736
ENST00000380377
O75347 [Direct mapping]
Tubulin-specific chaperone A
Q6FGD7 [Target identity:100%; Query identity:100%]
TBCA protein; Tubulin folding cofactor A; Tubulin-specific chaperone a; cDNA, FLJ92496, Homo sapiens tubulin-specific chaperone a (TBCA), mRNA
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0007021 [tubulin complex assembly]
GO:0007023 [post-chaperonin tubulin folding pathway]
GO:0015630 [microtubule cytoskeleton]
GO:0015631 [tubulin binding]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0051082 [unfolded protein binding]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0051087 [chaperone binding]
GO:0070062 [extracellular exosome]
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 108 aa
12.9 kDa 		No 0
TBCA-002
ENSP00000306362
ENST00000306388
O75347 [Direct mapping]
Tubulin-specific chaperone A
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0007021 [tubulin complex assembly]
GO:0007023 [post-chaperonin tubulin folding pathway]
GO:0015630 [microtubule cytoskeleton]
GO:0015631 [tubulin binding]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0051082 [unfolded protein binding]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0051087 [chaperone binding]
GO:0070062 [extracellular exosome]
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 129 aa
15.8 kDa 		No 0
TBCA-003
ENSP00000429083
ENST00000517679
E5RJD8 [Direct mapping]
Tubulin-specific chaperone A
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   Phobius predicted membrane proteins
   SignalP predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005730 [nucleolus]
GO:0007021 [tubulin complex assembly]
GO:0015630 [microtubule cytoskeleton]
GO:0015631 [tubulin binding]
GO:0051082 [unfolded protein binding]
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 119 aa
14.3 kDa 		No 0
TBCA-004
ENSP00000429793
ENST00000518338
E5RHG6 [Direct mapping]
Tubulin-specific chaperone A
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007021 [tubulin complex assembly]
GO:0015631 [tubulin binding]
GO:0051082 [unfolded protein binding]
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 131 aa
15.1 kDa 		No 0
TBCA-005
ENSP00000429313
ENST00000522370
E5RIW3 [Direct mapping]
Tubulin-specific chaperone A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005730 [nucleolus]
GO:0007021 [tubulin complex assembly]
GO:0015630 [microtubule cytoskeleton]
GO:0015631 [tubulin binding]
GO:0051082 [unfolded protein binding]
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 84 aa
10.1 kDa 		No 0
TBCA-006
ENSP00000429288
ENST00000520361
E5RIX8 [Direct mapping]
Tubulin-specific chaperone A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007021 [tubulin complex assembly]
GO:0015631 [tubulin binding]
GO:0051082 [unfolded protein binding]
Show all
 79 aa
9.4 kDa 		No 0
TBCA-007
ENSP00000429046
ENST00000520039
E5RJM1 [Direct mapping]
Tubulin-specific chaperone A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 26 aa
3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.