Cell atlas - TBCA - The Human Protein Atlas

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TBCA

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Microtubules
	Nucleoli

Human cell
	Microtubules
	Nucleoli

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GENERAL INFORMATION
Gene name	TBCA
Gene description	Tubulin folding cofactor A
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the microtubules. In addition localized to the nucleoli.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Microtubules (supported)
Additional location	In addition localized to the Nucleoli (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA036487
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the microtubules. In addition localized to the nucleoli.

Main location

Microtubules (supported)

Additional location

Nucleoli (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA036487	A-431	Nucleoli
	HPA036487	A-431	Microtubules
	HPA036487	U-2 OS	Nucleoli
	HPA036487	U-2 OS	Microtubules
	HPA036487	U-251 MG	Nucleoli
	HPA036487	U-251 MG	Microtubules

GENE INFORMATION
Gene name	TBCA
Synonyms
Description	Tubulin folding cofactor A (HGNC Symbol)
Entrez gene summary	The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Chromosome	5
Cytoband	q14.1
Chromosome location (bp)	77691166 - 77868780
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171530 (version 83.38)
Entrez gene	6902
UniProt	O75347 (UniProt - Evidence at protein level)
neXtProt	NX_O75347
Antibodypedia	TBCA antibodies

PROTEIN BROWSER

TBCA-001	TBCA-002	TBCA-003	TBCA-004	TBCA-005	TBCA-006	TBCA-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TBCA-001 ENSP00000369736 ENST00000380377	O75347 [Direct mapping] Tubulin-specific chaperone A Q6FGD7 [Target identity:100%; Query identity:100%] TBCA protein; Tubulin folding cofactor A; Tubulin-specific chaperone a; cDNA, FLJ92496, Homo sapiens tubulin-specific chaperone a (TBCA), mRNA Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0006457 [protein folding] GO:0007021 [tubulin complex assembly] GO:0007023 [post-chaperonin tubulin folding pathway] GO:0015630 [microtubule cytoskeleton] GO:0015631 [tubulin binding] GO:0044267 [cellular protein metabolic process] GO:0044822 [poly(A) RNA binding] GO:0051082 [unfolded protein binding] GO:0051084 ['de novo' posttranslational protein folding] GO:0051087 [chaperone binding] GO:0070062 [extracellular exosome] Show all	108 aa 12.9 kDa	No	0
TBCA-002 ENSP00000306362 ENST00000306388	O75347 [Direct mapping] Tubulin-specific chaperone A Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0006457 [protein folding] GO:0007021 [tubulin complex assembly] GO:0007023 [post-chaperonin tubulin folding pathway] GO:0015630 [microtubule cytoskeleton] GO:0015631 [tubulin binding] GO:0044267 [cellular protein metabolic process] GO:0044822 [poly(A) RNA binding] GO:0051082 [unfolded protein binding] GO:0051084 ['de novo' posttranslational protein folding] GO:0051087 [chaperone binding] GO:0070062 [extracellular exosome] Show all	129 aa 15.8 kDa	No	0
TBCA-003 ENSP00000429083 ENST00000517679	E5RJD8 [Direct mapping] Tubulin-specific chaperone A Show all	Phobius predicted membrane proteins SignalP predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005730 [nucleolus] GO:0007021 [tubulin complex assembly] GO:0015630 [microtubule cytoskeleton] GO:0015631 [tubulin binding] GO:0051082 [unfolded protein binding] Show all	119 aa 14.3 kDa	No	0
TBCA-004 ENSP00000429793 ENST00000518338	E5RHG6 [Direct mapping] Tubulin-specific chaperone A Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007021 [tubulin complex assembly] GO:0015631 [tubulin binding] GO:0051082 [unfolded protein binding] Show all	131 aa 15.1 kDa	No	0
TBCA-005 ENSP00000429313 ENST00000522370	E5RIW3 [Direct mapping] Tubulin-specific chaperone A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005730 [nucleolus] GO:0007021 [tubulin complex assembly] GO:0015630 [microtubule cytoskeleton] GO:0015631 [tubulin binding] GO:0051082 [unfolded protein binding] Show all	84 aa 10.1 kDa	No	0
TBCA-006 ENSP00000429288 ENST00000520361	E5RIX8 [Direct mapping] Tubulin-specific chaperone A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007021 [tubulin complex assembly] GO:0015631 [tubulin binding] GO:0051082 [unfolded protein binding] Show all	79 aa 9.4 kDa	No	0
TBCA-007 ENSP00000429046 ENST00000520039	E5RJM1 [Direct mapping] Tubulin-specific chaperone A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		26 aa 3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.