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Several cases of hepatocellular carcinoma along with rare pancreatic, lung cancers and melanoma showed moderate cytoplasmic positivity. A single case of carcinoid showed strong positivity. Remaining cancers were weakly stained or negative.
Few renal cancers showed moderate cytoplasmic immunoreactivity. Fraction of cells in a single case of hepatocellular carcinoma was strongly stained. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
FGA
Synonyms
Description
Fibrinogen alpha chain (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus. [provided by RefSeq, Jul 2008]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002250 [adaptive immune response] GO:0002576 [platelet degranulation] GO:0005102 [receptor binding] GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005577 [fibrinogen complex] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0007160 [cell-matrix adhesion] GO:0007165 [signal transduction] GO:0007596 [blood coagulation] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0030168 [platelet activation] GO:0030198 [extracellular matrix organization] GO:0030674 [protein binding, bridging] GO:0031091 [platelet alpha granule] GO:0031093 [platelet alpha granule lumen] GO:0031639 [plasminogen activation] GO:0034116 [positive regulation of heterotypic cell-cell adhesion] GO:0042730 [fibrinolysis] GO:0043152 [induction of bacterial agglutination] GO:0043623 [cellular protein complex assembly] GO:0044267 [cellular protein metabolic process] GO:0045087 [innate immune response] GO:0045907 [positive regulation of vasoconstriction] GO:0045921 [positive regulation of exocytosis] GO:0050714 [positive regulation of protein secretion] GO:0050839 [cell adhesion molecule binding] GO:0051258 [protein polymerization] GO:0051592 [response to calcium ion] GO:0070062 [extracellular exosome] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070527 [platelet aggregation] GO:0072377 [blood coagulation, common pathway] GO:0072378 [blood coagulation, fibrin clot formation] GO:0072562 [blood microparticle] GO:0090277 [positive regulation of peptide hormone secretion] GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1903561 [extracellular vesicle] GO:2000261 [negative regulation of blood coagulation, common pathway] GO:2000352 [negative regulation of endothelial cell apoptotic process]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response] GO:0002576 [platelet degranulation] GO:0005102 [receptor binding] GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005577 [fibrinogen complex] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005791 [rough endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006461 [protein complex assembly] GO:0006953 [acute-phase response] GO:0007160 [cell-matrix adhesion] GO:0007165 [signal transduction] GO:0007596 [blood coagulation] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0030168 [platelet activation] GO:0030198 [extracellular matrix organization] GO:0030674 [protein binding, bridging] GO:0031091 [platelet alpha granule] GO:0031093 [platelet alpha granule lumen] GO:0031639 [plasminogen activation] GO:0032355 [response to estradiol] GO:0033595 [response to genistein] GO:0034116 [positive regulation of heterotypic cell-cell adhesion] GO:0042730 [fibrinolysis] GO:0043152 [induction of bacterial agglutination] GO:0043278 [response to morphine] GO:0043623 [cellular protein complex assembly] GO:0044267 [cellular protein metabolic process] GO:0045087 [innate immune response] GO:0045907 [positive regulation of vasoconstriction] GO:0045921 [positive regulation of exocytosis] GO:0046898 [response to cycloheximide] GO:0050714 [positive regulation of protein secretion] GO:0050839 [cell adhesion molecule binding] GO:0051258 [protein polymerization] GO:0051592 [response to calcium ion] GO:0070062 [extracellular exosome] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070527 [platelet aggregation] GO:0071345 [cellular response to cytokine stimulus] GO:0071354 [cellular response to interleukin-6] GO:0071407 [cellular response to organic cyclic compound] GO:0072377 [blood coagulation, common pathway] GO:0072378 [blood coagulation, fibrin clot formation] GO:0072562 [blood microparticle] GO:0090277 [positive regulation of peptide hormone secretion] GO:0097421 [liver regeneration] GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1903561 [extracellular vesicle] GO:1990643 [cellular response to granulocyte colony-stimulating factor] GO:2000261 [negative regulation of blood coagulation, common pathway] GO:2000352 [negative regulation of endothelial cell apoptotic process]