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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

FGA

Gene description

Fibrinogen alpha chain

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (liver)
GTEx:Tissue enriched (liver)
FANTOM5:Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression

Distinct plasma positivity.

DATA RELIABILITY

Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.

Reliability score

Supported based on 3 antibodies.
HPA051370 , HPA064755 , CAB016776
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)

GENE INFORMATION

Gene name

FGA

Synonyms

Description

Fibrinogen alpha chain (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

q31.3

Chromosome location (bp)

154583126 - 154590766

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000171560 (version 83.38)

Entrez gene

2243

UniProt

P02671 (UniProt - Evidence at protein level)

neXtProt

NX_P02671

Antibodypedia

FGA antibodies

PROTEIN BROWSER

FGA-001
FGA-002
FGA-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FGA-001
ENSP00000385981
ENST00000403106
P02671 [Direct mapping]
Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0002576 [platelet degranulation]
GO:0005102 [receptor binding]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0007160 [cell-matrix adhesion]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0030674 [protein binding, bridging]
GO:0031091 [platelet alpha granule]
GO:0031093 [platelet alpha granule lumen]
GO:0031639 [plasminogen activation]
GO:0034116 [positive regulation of heterotypic cell-cell adhesion]
GO:0042730 [fibrinolysis]
GO:0043152 [induction of bacterial agglutination]
GO:0043623 [cellular protein complex assembly]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045907 [positive regulation of vasoconstriction]
GO:0045921 [positive regulation of exocytosis]
GO:0050714 [positive regulation of protein secretion]
GO:0050839 [cell adhesion molecule binding]
GO:0051258 [protein polymerization]
GO:0051592 [response to calcium ion]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070527 [platelet aggregation]
GO:0072377 [blood coagulation, common pathway]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:0072562 [blood microparticle]
GO:0090277 [positive regulation of peptide hormone secretion]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1903561 [extracellular vesicle]
GO:2000261 [negative regulation of blood coagulation, common pathway]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
Show all
644 aa
69.8 kDa
Yes 0
FGA-002
ENSP00000306361
ENST00000302053
P02671 [Direct mapping]
Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0002576 [platelet degranulation]
GO:0005102 [receptor binding]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005791 [rough endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006461 [protein complex assembly]
GO:0006953 [acute-phase response]
GO:0007160 [cell-matrix adhesion]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0030674 [protein binding, bridging]
GO:0031091 [platelet alpha granule]
GO:0031093 [platelet alpha granule lumen]
GO:0031639 [plasminogen activation]
GO:0032355 [response to estradiol]
GO:0033595 [response to genistein]
GO:0034116 [positive regulation of heterotypic cell-cell adhesion]
GO:0042730 [fibrinolysis]
GO:0043152 [induction of bacterial agglutination]
GO:0043278 [response to morphine]
GO:0043623 [cellular protein complex assembly]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045907 [positive regulation of vasoconstriction]
GO:0045921 [positive regulation of exocytosis]
GO:0046898 [response to cycloheximide]
GO:0050714 [positive regulation of protein secretion]
GO:0050839 [cell adhesion molecule binding]
GO:0051258 [protein polymerization]
GO:0051592 [response to calcium ion]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070527 [platelet aggregation]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071354 [cellular response to interleukin-6]
GO:0071407 [cellular response to organic cyclic compound]
GO:0072377 [blood coagulation, common pathway]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:0072562 [blood microparticle]
GO:0090277 [positive regulation of peptide hormone secretion]
GO:0097421 [liver regeneration]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1903561 [extracellular vesicle]
GO:1990643 [cellular response to granulocyte colony-stimulating factor]
GO:2000261 [negative regulation of blood coagulation, common pathway]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
Show all
866 aa
95 kDa
Yes 0
FGA-201
ENSP00000478487
ENST00000622532
A0A087WUA0 [Direct mapping]
Fibrinogen alpha chain
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005577 [fibrinogen complex]
GO:0007165 [signal transduction]
GO:0030168 [platelet activation]
GO:0030674 [protein binding, bridging]
GO:0051258 [protein polymerization]
Show all
289 aa
33 kDa
Yes 0

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