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Tumour cells were generally negative. Several cases of colorectal cancer and a few cases of cervical and endometrial cancers showed moderate to strong cytoplasmic positivity in a fraction of cells.
The protein encoded by this gene belongs to the dynein intermediate chain family, and is part of the dynein complex of respiratory cilia and sperm flagella. Mutations in this gene are associated with primary ciliary dyskinesia type 9. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2010]