Fields »
ABOUT
HELP
BLOG
DNAI2

GENERAL INFORMATION

Gene name

 DNAI2

Gene description

 Dynein, axonemal, intermediate chain 2

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (fallopian tube, testis)
GTEx:Group enriched (testis, fallopian tube)
FANTOM5:Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Selective expression in cilia including spermatocytes.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA050565 , CAB006245
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Fallopian tube

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (fallopian tube, testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (testis, fallopian tube)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)

GENE INFORMATION

Gene name

 DNAI2 (HGNC Symbol)

Synonyms

 CILD9, DIC2

Description

 Dynein, axonemal, intermediate chain 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the dynein intermediate chain family, and is part of the dynein complex of respiratory cilia and sperm flagella. Mutations in this gene are associated with primary ciliary dyskinesia type 9. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2010]

Chromosome

 17

Cytoband

 q25.1

Chromosome location (bp)

 74274247 - 74314884

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171595 (version 83.38)

Entrez gene

 64446

UniProt

 Q9GZS0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9GZS0

Antibodypedia

 DNAI2 antibodies

PROTEIN BROWSER
DNAI2-001
DNAI2-003
DNAI2-004
DNAI2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DNAI2-001
ENSP00000308312
ENST00000311014
Q9GZS0 [Direct mapping]
Dynein intermediate chain 2, axonemal
Show all
Predicted intracellular proteins
Disease related genes
Show all
GO:0003341 [cilium movement]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005858 [axonemal dynein complex]
GO:0005874 [microtubule]
GO:0005930 [axoneme]
GO:0007368 [determination of left/right symmetry]
GO:0008152 [metabolic process]
GO:0036126 [sperm flagellum]
GO:0036157 [outer dynein arm]
GO:0036158 [outer dynein arm assembly]
GO:0042384 [cilium assembly]
Show all
 605 aa
68.8 kDa 		No 0
DNAI2-003
ENSP00000461950
ENST00000582036
Q9GZS0 [Direct mapping]
Dynein intermediate chain 2, axonemal
Show all
Predicted intracellular proteins
Disease related genes
Show all
GO:0003341 [cilium movement]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005858 [axonemal dynein complex]
GO:0005874 [microtubule]
GO:0005930 [axoneme]
GO:0007368 [determination of left/right symmetry]
GO:0008152 [metabolic process]
GO:0036126 [sperm flagellum]
GO:0036157 [outer dynein arm]
GO:0036158 [outer dynein arm assembly]
GO:0042384 [cilium assembly]
Show all
 593 aa
67.4 kDa 		No 0
DNAI2-004
ENSP00000464197
ENST00000579490
J3QRG2 [Direct mapping]
Dynein intermediate chain 2, axonemal
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
Show all
 662 aa
74.8 kDa 		No 0
DNAI2-201
ENSP00000400252
ENST00000446837
Q9GZS0 [Direct mapping]
Dynein intermediate chain 2, axonemal
Show all
Predicted intracellular proteins
Disease related genes
Show all
GO:0003341 [cilium movement]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005858 [axonemal dynein complex]
GO:0005874 [microtubule]
GO:0005930 [axoneme]
GO:0007368 [determination of left/right symmetry]
GO:0008152 [metabolic process]
GO:0009897 [external side of plasma membrane]
GO:0036126 [sperm flagellum]
GO:0036157 [outer dynein arm]
GO:0036158 [outer dynein arm assembly]
GO:0042384 [cilium assembly]
Show all
 605 aa
68.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.