Expression of GPR34 in cancer - Summary

CANCER ATLAS

Gene description

G protein-coupled receptor 34

Protein class

G-protein coupled receptors, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA010668	CAB025490

GENE INFORMATION
Gene name	GPR34
Synonyms
Description	G protein-coupled receptor 34 (HGNC Symbol)
Entrez gene summary	G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM, Apr 2006]
Chromosome	X
Cytoband	p11.4
Chromosome location (bp)	41688973 - 41697277
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171659 (version 83.38)
Entrez gene	2857
UniProt	Q9UPC5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9UPC5
Antibodypedia	GPR34 antibodies

PROTEIN BROWSER

GPR34-001	GPR34-002	GPR34-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPR34-001 ENSP00000367384 ENST00000378142	Q9UPC5 [Direct mapping] Probable G-protein coupled receptor 34 Q5VT14 [Target identity:100%; Query identity:100%] G protein-coupled receptor 34; G protein-coupled receptor 34, isoform CRA_a; G-protein-coupled receptor 34 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway] GO:0045028 [G-protein coupled purinergic nucleotide receptor activity] Show all	381 aa 43.9 kDa	No	7
GPR34-002 ENSP00000367378 ENST00000378138	Q9UPC5 [Direct mapping] Probable G-protein coupled receptor 34 Q5VT14 [Target identity:100%; Query identity:100%] G protein-coupled receptor 34; G protein-coupled receptor 34, isoform CRA_a; G-protein-coupled receptor 34 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway] GO:0045028 [G-protein coupled purinergic nucleotide receptor activity] Show all	381 aa 43.9 kDa	No	7
GPR34-201 ENSP00000480296 ENST00000620846	Q3SAH0 [Direct mapping] G-protein-coupled receptor 34 splice variant; Probable G-protein-coupled receptor 34 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway] GO:0045028 [G-protein coupled purinergic nucleotide receptor activity] Show all	334 aa 38.5 kDa	No	7