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GPR34

GENERAL INFORMATION

Gene name

 GPR34

Gene description

 G protein-coupled receptor 34

Protein class

 G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA010668 , CAB025490
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Breast

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 GPR34

Synonyms

Description

 G protein-coupled receptor 34 (HGNC Symbol)

Entrez gene summary

 G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM, Apr 2006]

Chromosome

 X

Cytoband

 p11.4

Chromosome location (bp)

 41688973 - 41697277

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171659 (version 83.38)

Entrez gene

 2857

UniProt

 Q9UPC5 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9UPC5

Antibodypedia

 GPR34 antibodies

PROTEIN BROWSER
GPR34-001
GPR34-002
GPR34-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GPR34-001
ENSP00000367384
ENST00000378142
Q9UPC5 [Direct mapping]
Probable G-protein coupled receptor 34
Q5VT14 [Target identity:100%; Query identity:100%]
G protein-coupled receptor 34; G protein-coupled receptor 34, isoform CRA_a; G-protein-coupled receptor 34
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G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway]
GO:0045028 [G-protein coupled purinergic nucleotide receptor activity]
Show all
 381 aa
43.9 kDa 		No 7
GPR34-002
ENSP00000367378
ENST00000378138
Q9UPC5 [Direct mapping]
Probable G-protein coupled receptor 34
Q5VT14 [Target identity:100%; Query identity:100%]
G protein-coupled receptor 34; G protein-coupled receptor 34, isoform CRA_a; G-protein-coupled receptor 34
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway]
GO:0045028 [G-protein coupled purinergic nucleotide receptor activity]
Show all
 381 aa
43.9 kDa 		No 7
GPR34-201
ENSP00000480296
ENST00000620846
Q3SAH0 [Direct mapping]
G-protein-coupled receptor 34 splice variant; Probable G-protein-coupled receptor 34
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway]
GO:0045028 [G-protein coupled purinergic nucleotide receptor activity]
Show all
 334 aa
38.5 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.