Tissue expression of AQP4 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	AQP4
Gene description	Aquaporin 4
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (cerebral cortex, lung)
GTEx:	Tissue enhanced (caudate, hypothalamus, hippocampus, cerebral cortex)
FANTOM5:	Group enriched (hippocampus, caudate, brain, cerebellum)

Protein evidence

Evidence at protein level

Protein expression

Selective expression in CNS, lung, thyroid gland and stomach.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA014784 , CAB005079 , CAB058689
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (cerebral cortex, lung)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (caudate, hypothalamus, hippocampus, cerebral cortex)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (hippocampus, caudate, brain, cerebellum)

GENE INFORMATION
Gene name	AQP4 (HGNC Symbol)
Synonyms	MIWC
Description	Aquaporin 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015]
Chromosome	18
Cytoband	q11.2
Chromosome location (bp)	26852038 - 26865818
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171885 (version 83.38)
Entrez gene	361
UniProt	P55087 (UniProt - Evidence at protein level)
neXtProt	NX_P55087
Antibodypedia	AQP4 antibodies

PROTEIN BROWSER

AQP4-001	AQP4-002	AQP4-003	AQP4-005	AQP4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AQP4-001 ENSP00000372654 ENST00000383168	P55087 [Direct mapping] Aquaporin-4 F1DSG4 [Target identity:100%; Query identity:100%] Aquaporin 4 transcript variant a; Aquaporin 4, isoform CRA_a Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003091 [renal water homeostasis] GO:0005215 [transporter activity] GO:0005372 [water transmembrane transporter activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006833 [water transport] GO:0009897 [external side of plasma membrane] GO:0009992 [cellular water homeostasis] GO:0015250 [water channel activity] GO:0015254 [glycerol channel activity] GO:0015793 [glycerol transport] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0034220 [ion transmembrane transport] GO:0050891 [multicellular organismal water homeostasis] GO:0055085 [transmembrane transport] GO:0071346 [cellular response to interferon-gamma] Show all	323 aa 34.8 kDa	No	6
AQP4-002 ENSP00000462075 ENST00000578776	J3KRM4 [Direct mapping] Aquaporin-4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006833 [water transport] GO:0009992 [cellular water homeostasis] GO:0015250 [water channel activity] GO:0015254 [glycerol channel activity] GO:0015793 [glycerol transport] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0034220 [ion transmembrane transport] Show all	185 aa 19.2 kDa	No	4
AQP4-003 ENSP00000462597 ENST00000581374	P55087 [Direct mapping] Aquaporin-4 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003091 [renal water homeostasis] GO:0005215 [transporter activity] GO:0005372 [water transmembrane transporter activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006833 [water transport] GO:0009897 [external side of plasma membrane] GO:0009992 [cellular water homeostasis] GO:0015250 [water channel activity] GO:0015254 [glycerol channel activity] GO:0015793 [glycerol transport] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0034220 [ion transmembrane transport] GO:0050891 [multicellular organismal water homeostasis] GO:0055085 [transmembrane transport] GO:0071346 [cellular response to interferon-gamma] Show all	301 aa 32.3 kDa	No	6
AQP4-005 ENSP00000393121 ENST00000440832	P55087 [Direct mapping] Aquaporin-4 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003091 [renal water homeostasis] GO:0005215 [transporter activity] GO:0005372 [water transmembrane transporter activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006833 [water transport] GO:0009897 [external side of plasma membrane] GO:0009992 [cellular water homeostasis] GO:0015250 [water channel activity] GO:0015254 [glycerol channel activity] GO:0015793 [glycerol transport] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0034220 [ion transmembrane transport] GO:0050891 [multicellular organismal water homeostasis] GO:0055085 [transmembrane transport] GO:0071346 [cellular response to interferon-gamma] Show all	301 aa 32.3 kDa	No	6
AQP4-201 ENSP00000484446 ENST00000622234	V9PBN7 [Direct mapping] Aquaporin 4 isoform delta4; Aquaporin-4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006833 [water transport] GO:0009992 [cellular water homeostasis] GO:0015250 [water channel activity] GO:0015254 [glycerol channel activity] GO:0015793 [glycerol transport] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0034220 [ion transmembrane transport] Show all	296 aa 31.8 kDa	No	5