Expression of ATPAF2 in cancer - Summary

CANCER ATLAS

Gene description

ATP synthase mitochondrial F1 complex assembly factor 2

Protein class

Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA023329

GENE INFORMATION
Gene name	ATPAF2 (HGNC Symbol)
Synonyms	ATP12, Atp12p, LP3663, MGC29736
Description	ATP synthase mitochondrial F1 complex assembly factor 2 (HGNC Symbol)
Entrez gene summary	This gene encodes an assembly factor for the F(1) component of the mitochondrial ATP synthase. This protein binds specifically to the F1 alpha subunit and is thought to prevent this subunit from forming nonproductive homooligomers during enzyme assembly. This gene is located within the Smith-Magenis syndrome region on chromosome 17. An alternatively spliced transcript variant has been described, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p11.2
Chromosome location (bp)	17977409 - 18039209
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171953 (version 83.38)
Entrez gene	91647
UniProt	Q8N5M1 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N5M1
Antibodypedia	ATPAF2 antibodies

PROTEIN BROWSER

ATPAF2-001	ATPAF2-013	ATPAF2-014	ATPAF2-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATPAF2-001 ENSP00000417190 ENST00000474627	Q8N5M1 [Direct mapping] ATP synthase mitochondrial F1 complex assembly factor 2 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0016607 [nuclear speck] GO:0043461 [proton-transporting ATP synthase complex assembly] Show all	289 aa 32.8 kDa	No	0
ATPAF2-013 ENSP00000463861 ENST00000585101	J3KTB2 [Direct mapping] ATP synthase mitochondrial F1 complex assembly factor 2; ATP synthase mitochondrial F1 complex assembly factor 2, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		107 aa 11.6 kDa	No	0
ATPAF2-014 ENSP00000466008 ENST00000581698	K7ELC1 [Direct mapping] ATP synthase mitochondrial F1 complex assembly factor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		59 aa 6.1 kDa	No	0
ATPAF2-015 ENSP00000397198 ENST00000444058	C9J2Q2 [Direct mapping] ATP synthase mitochondrial F1 complex assembly factor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0043461 [proton-transporting ATP synthase complex assembly] Show all	205 aa 23.2 kDa	No	0