Cell atlas - ATPAF2 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

ATPAF2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	ATPAF2
Gene description	ATP synthase mitochondrial F1 complex assembly factor 2
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (validated)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA023329 , HPA059422
	SHOW MORE

ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA023329	A-431	Cytosol	Intensity
HPA023329	U-2 OS	Cytosol	Intensity
HPA023329	U-251 MG	Cytosol	Intensity
HPA059422	A-431	Cytosol	Intensity
HPA059422	U-2 OS	Cytosol
HPA059422	U-251 MG	Cytosol

GENE INFORMATION
Gene name	ATPAF2 (HGNC Symbol)
Synonyms	ATP12, Atp12p, LP3663, MGC29736
Description	ATP synthase mitochondrial F1 complex assembly factor 2 (HGNC Symbol)
Entrez gene summary	This gene encodes an assembly factor for the F(1) component of the mitochondrial ATP synthase. This protein binds specifically to the F1 alpha subunit and is thought to prevent this subunit from forming nonproductive homooligomers during enzyme assembly. This gene is located within the Smith-Magenis syndrome region on chromosome 17. An alternatively spliced transcript variant has been described, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p11.2
Chromosome location (bp)	17977409 - 18039209
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171953 (version 83.38)
Entrez gene	91647
UniProt	Q8N5M1 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N5M1
Antibodypedia	ATPAF2 antibodies

PROTEIN BROWSER

ATPAF2-001	ATPAF2-013	ATPAF2-014	ATPAF2-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATPAF2-001 ENSP00000417190 ENST00000474627	Q8N5M1 [Direct mapping] ATP synthase mitochondrial F1 complex assembly factor 2 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0016607 [nuclear speck] GO:0043461 [proton-transporting ATP synthase complex assembly] Show all	289 aa 32.8 kDa	No	0
ATPAF2-013 ENSP00000463861 ENST00000585101	J3KTB2 [Direct mapping] ATP synthase mitochondrial F1 complex assembly factor 2; ATP synthase mitochondrial F1 complex assembly factor 2, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		107 aa 11.6 kDa	No	0
ATPAF2-014 ENSP00000466008 ENST00000581698	K7ELC1 [Direct mapping] ATP synthase mitochondrial F1 complex assembly factor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		59 aa 6.1 kDa	No	0
ATPAF2-015 ENSP00000397198 ENST00000444058	C9J2Q2 [Direct mapping] ATP synthase mitochondrial F1 complex assembly factor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0043461 [proton-transporting ATP synthase complex assembly] Show all	205 aa 23.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.