Expression of PPIH in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Peptidylprolyl isomerase H (cyclophilin H)

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA059019

GENE INFORMATION
Gene name	PPIH (HGNC Symbol)
Synonyms	CYP-20, CYPH, MGC5016, SnuCyp-20, USA-CYP
Description	Peptidylprolyl isomerase H (cyclophilin H) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p34.2
Chromosome location (bp)	42658425 - 42676758
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171960 (version 83.38)
Entrez gene	10465
UniProt	O43447 (UniProt - Evidence at protein level)
neXtProt	NX_O43447
Antibodypedia	PPIH antibodies

PROTEIN BROWSER

PPIH-001	PPIH-002	PPIH-003	PPIH-004	PPIH-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPIH-001 ENSP00000306614 ENST00000304979	O43447 [Direct mapping] Peptidyl-prolyl cis-trans isomerase H Q6FH36 [Target identity:100%; Query identity:100%] Peptidyl-prolyl cis-trans isomerase Show all	Enzymes ENZYME proteins Isomerase Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005515 [protein binding] GO:0005681 [spliceosomal complex] GO:0005737 [cytoplasm] GO:0006457 [protein folding] GO:0006461 [protein complex assembly] GO:0016018 [cyclosporin A binding] GO:0016607 [nuclear speck] GO:0043021 [ribonucleoprotein complex binding] GO:0045070 [positive regulation of viral genome replication] GO:0046540 [U4/U6 x U5 tri-snRNP complex] GO:0071001 [U4/U6 snRNP] Show all	177 aa 19.2 kDa	No	0
PPIH-002 ENSP00000402836 ENST00000440068	C9JQD4 [Direct mapping] Peptidyl-prolyl cis-trans isomerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0006457 [protein folding] Show all	144 aa 15.8 kDa	No	0
PPIH-003 ENSP00000361629 ENST00000372549	A6NM32 [Direct mapping] Peptidyl-prolyl cis-trans isomerase H Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0006457 [protein folding] Show all	57 aa 6.3 kDa	No	0
PPIH-004 ENSP00000361630 ENST00000372550	O43447 [Direct mapping] Peptidyl-prolyl cis-trans isomerase H Show all	Enzymes ENZYME proteins Isomerase Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005515 [protein binding] GO:0005681 [spliceosomal complex] GO:0005737 [cytoplasm] GO:0006457 [protein folding] GO:0006461 [protein complex assembly] GO:0016018 [cyclosporin A binding] GO:0016607 [nuclear speck] GO:0043021 [ribonucleoprotein complex binding] GO:0045070 [positive regulation of viral genome replication] GO:0046540 [U4/U6 x U5 tri-snRNP complex] GO:0071001 [U4/U6 snRNP] Show all	134 aa 14.5 kDa	No	0
PPIH-005 ENSP00000405493 ENST00000436387	C9JAN8 [Direct mapping] Peptidyl-prolyl cis-trans isomerase Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0006457 [protein folding] Show all	68 aa 7.6 kDa	No	0