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PPIH

GENERAL INFORMATION

Gene name

 PPIH

Gene description

 Peptidylprolyl isomerase H (cyclophilin H)

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA059019
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Smooth muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PPIH (HGNC Symbol)

Synonyms

 CYP-20, CYPH, MGC5016, SnuCyp-20, USA-CYP

Description

 Peptidylprolyl isomerase H (cyclophilin H) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p34.2

Chromosome location (bp)

 42658425 - 42676758

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171960 (version 83.38)

Entrez gene

 10465

UniProt

 O43447 (UniProt - Evidence at protein level)

neXtProt

 NX_O43447

Antibodypedia

 PPIH antibodies

PROTEIN BROWSER
PPIH-001
PPIH-002
PPIH-003
PPIH-004
PPIH-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPIH-001
ENSP00000306614
ENST00000304979
O43447 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase H
Q6FH36 [Target identity:100%; Query identity:100%]
Peptidyl-prolyl cis-trans isomerase
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005515 [protein binding]
GO:0005681 [spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0006457 [protein folding]
GO:0006461 [protein complex assembly]
GO:0016018 [cyclosporin A binding]
GO:0016607 [nuclear speck]
GO:0043021 [ribonucleoprotein complex binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
GO:0071001 [U4/U6 snRNP]
Show all
 177 aa
19.2 kDa 		No 0
PPIH-002
ENSP00000402836
ENST00000440068
C9JQD4 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0006457 [protein folding]
Show all
 144 aa
15.8 kDa 		No 0
PPIH-003
ENSP00000361629
ENST00000372549
A6NM32 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase H
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0006457 [protein folding]
Show all
 57 aa
6.3 kDa 		No 0
PPIH-004
ENSP00000361630
ENST00000372550
O43447 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase H
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005515 [protein binding]
GO:0005681 [spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0006457 [protein folding]
GO:0006461 [protein complex assembly]
GO:0016018 [cyclosporin A binding]
GO:0016607 [nuclear speck]
GO:0043021 [ribonucleoprotein complex binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
GO:0071001 [U4/U6 snRNP]
Show all
 134 aa
14.5 kDa 		No 0
PPIH-005
ENSP00000405493
ENST00000436387
C9JAN8 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0006457 [protein folding]
Show all
 68 aa
7.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.