Expression of REG3A in cancer - Summary

CANCER ATLAS

Gene description

Regenerating islet-derived 3 alpha

Protein class

Plasma proteins, Predicted secreted proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA047894	HPA048334

GENE INFORMATION
Gene name	REG3A (HGNC Symbol)
Synonyms	HIP, PAP, PAP1, PBCGF, REG-III, REG3
Description	Regenerating islet-derived 3 alpha (HGNC Symbol)
Entrez gene summary	This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with antibacterial activity. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Nov 2014]
Chromosome	2
Cytoband	p12
Chromosome location (bp)	79157003 - 79159753
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172016 (version 83.38)
Entrez gene	5068
UniProt	Q06141 (UniProt - Evidence at protein level)
neXtProt	NX_Q06141
Antibodypedia	REG3A antibodies

PROTEIN BROWSER

REG3A-001	REG3A-002	REG3A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
REG3A-001 ENSP00000386630 ENST00000409839	Q06141 [Direct mapping] Regenerating islet-derived protein 3-alpha Regenerating islet-derived protein 3-alpha 16.5 kDa form Regenerating islet-derived protein 3-alpha 15 kDa form Q53S56 [Target identity:100%; Query identity:100%] Proliferation-inducing protein 34; Proliferation-inducing protein 42; Putative uncharacterized protein PAP; Regenerating islet-derived 3 alpha, isoform CRA_a; cDNA FLJ76569, highly similar to Homo sapiens regenerating islet-derived 3 alpha (REG3A), transcript variant 1, mRNA Show all	Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006953 [acute-phase response] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007275 [multicellular organismal development] GO:0008283 [cell proliferation] GO:0010838 [positive regulation of keratinocyte proliferation] GO:0030246 [carbohydrate binding] GO:0045617 [negative regulation of keratinocyte differentiation] GO:0090303 [positive regulation of wound healing] Show all	175 aa 19.4 kDa	Yes	0
REG3A-002 ENSP00000304311 ENST00000305165	Q06141 [Direct mapping] Regenerating islet-derived protein 3-alpha Regenerating islet-derived protein 3-alpha 16.5 kDa form Regenerating islet-derived protein 3-alpha 15 kDa form Q53S56 [Target identity:100%; Query identity:100%] Proliferation-inducing protein 34; Proliferation-inducing protein 42; Putative uncharacterized protein PAP; Regenerating islet-derived 3 alpha, isoform CRA_a; cDNA FLJ76569, highly similar to Homo sapiens regenerating islet-derived 3 alpha (REG3A), transcript variant 1, mRNA Show all	Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006953 [acute-phase response] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007275 [multicellular organismal development] GO:0008283 [cell proliferation] GO:0010838 [positive regulation of keratinocyte proliferation] GO:0030246 [carbohydrate binding] GO:0045617 [negative regulation of keratinocyte differentiation] GO:0090303 [positive regulation of wound healing] Show all	175 aa 19.4 kDa	Yes	0
REG3A-201 ENSP00000377456 ENST00000393878	Q06141 [Direct mapping] Regenerating islet-derived protein 3-alpha Regenerating islet-derived protein 3-alpha 16.5 kDa form Regenerating islet-derived protein 3-alpha 15 kDa form Q53S56 [Target identity:100%; Query identity:100%] Proliferation-inducing protein 34; Proliferation-inducing protein 42; Putative uncharacterized protein PAP; Regenerating islet-derived 3 alpha, isoform CRA_a; cDNA FLJ76569, highly similar to Homo sapiens regenerating islet-derived 3 alpha (REG3A), transcript variant 1, mRNA Show all	Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006953 [acute-phase response] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007275 [multicellular organismal development] GO:0008283 [cell proliferation] GO:0010838 [positive regulation of keratinocyte proliferation] GO:0030246 [carbohydrate binding] GO:0045617 [negative regulation of keratinocyte differentiation] GO:0090303 [positive regulation of wound healing] Show all	175 aa 19.4 kDa	Yes	0