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REG3A

GENERAL INFORMATION

Gene name

 REG3A

Gene description

 Regenerating islet-derived 3 alpha

Protein class

 Plasma proteins
Predicted secreted proteins
Transporters

Predicted localization

 Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (small intestine, duodenum)
GTEx:Group enriched (pancreas, small intestine)
FANTOM5:Group enriched (pancreas, small intestine, colon)

Protein evidence

 Evidence at protein level

Protein expression

 Expression in a subset of cells in gastrointestinal tract.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 2 antibodies.
HPA047894 , HPA048334
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, duodenum)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (pancreas, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (pancreas, small intestine, colon)

GENE INFORMATION

Gene name

 REG3A (HGNC Symbol)

Synonyms

 HIP, PAP, PAP1, PBCGF, REG-III, REG3

Description

 Regenerating islet-derived 3 alpha (HGNC Symbol)

Entrez gene summary

 This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with antibacterial activity. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Nov 2014]

Chromosome

 2

Cytoband

 p12

Chromosome location (bp)

 79157003 - 79159753

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172016 (version 83.38)

Entrez gene

 5068

UniProt

 Q06141 (UniProt - Evidence at protein level)

neXtProt

 NX_Q06141

Antibodypedia

 REG3A antibodies

PROTEIN BROWSER
REG3A-001
REG3A-002
REG3A-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
REG3A-001
ENSP00000386630
ENST00000409839
Q06141 [Direct mapping]
Regenerating islet-derived protein 3-alpha Regenerating islet-derived protein 3-alpha 16.5 kDa form Regenerating islet-derived protein 3-alpha 15 kDa form
Q53S56 [Target identity:100%; Query identity:100%]
Proliferation-inducing protein 34; Proliferation-inducing protein 42; Putative uncharacterized protein PAP; Regenerating islet-derived 3 alpha, isoform CRA_a; cDNA FLJ76569, highly similar to Homo sapiens regenerating islet-derived 3 alpha (REG3A), transcript variant 1, mRNA
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Transporters
   Transporter channels and pores
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006953 [acute-phase response]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0007275 [multicellular organismal development]
GO:0008283 [cell proliferation]
GO:0010838 [positive regulation of keratinocyte proliferation]
GO:0030246 [carbohydrate binding]
GO:0045617 [negative regulation of keratinocyte differentiation]
GO:0090303 [positive regulation of wound healing]
Show all
 175 aa
19.4 kDa 		Yes 0
REG3A-002
ENSP00000304311
ENST00000305165
Q06141 [Direct mapping]
Regenerating islet-derived protein 3-alpha Regenerating islet-derived protein 3-alpha 16.5 kDa form Regenerating islet-derived protein 3-alpha 15 kDa form
Q53S56 [Target identity:100%; Query identity:100%]
Proliferation-inducing protein 34; Proliferation-inducing protein 42; Putative uncharacterized protein PAP; Regenerating islet-derived 3 alpha, isoform CRA_a; cDNA FLJ76569, highly similar to Homo sapiens regenerating islet-derived 3 alpha (REG3A), transcript variant 1, mRNA
Show all
Transporters
   Transporter channels and pores
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006953 [acute-phase response]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0007275 [multicellular organismal development]
GO:0008283 [cell proliferation]
GO:0010838 [positive regulation of keratinocyte proliferation]
GO:0030246 [carbohydrate binding]
GO:0045617 [negative regulation of keratinocyte differentiation]
GO:0090303 [positive regulation of wound healing]
Show all
 175 aa
19.4 kDa 		Yes 0
REG3A-201
ENSP00000377456
ENST00000393878
Q06141 [Direct mapping]
Regenerating islet-derived protein 3-alpha Regenerating islet-derived protein 3-alpha 16.5 kDa form Regenerating islet-derived protein 3-alpha 15 kDa form
Q53S56 [Target identity:100%; Query identity:100%]
Proliferation-inducing protein 34; Proliferation-inducing protein 42; Putative uncharacterized protein PAP; Regenerating islet-derived 3 alpha, isoform CRA_a; cDNA FLJ76569, highly similar to Homo sapiens regenerating islet-derived 3 alpha (REG3A), transcript variant 1, mRNA
Show all
Transporters
   Transporter channels and pores
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006953 [acute-phase response]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0007275 [multicellular organismal development]
GO:0008283 [cell proliferation]
GO:0010838 [positive regulation of keratinocyte proliferation]
GO:0030246 [carbohydrate binding]
GO:0045617 [negative regulation of keratinocyte differentiation]
GO:0090303 [positive regulation of wound healing]
Show all
 175 aa
19.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.