Cell atlas - CD8B - The Human Protein Atlas

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CD8B

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Plasma membrane

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	CD8B
Gene description	CD8b molecule
Protein class	CD markers Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane.
RNA cell category	Cell line enriched (RPMI-8226)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA029164
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (RPMI-8226) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane.

Main location

Plasma membrane (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA029164	CACO-2	Plasma membrane
	HPA029164	SH-SY5Y	No staining

GENE INFORMATION
Gene name	CD8B (HGNC Symbol)
Synonyms	CD8B1
Description	CD8b molecule (HGNC Symbol)
Entrez gene summary	The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010]
Chromosome	2
Cytoband	p11.2
Chromosome location (bp)	86815339 - 86861924
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172116 (version 83.38)
Entrez gene	926
UniProt	P10966 (UniProt - Evidence at transcript level)
neXtProt	NX_P10966
Antibodypedia	CD8B antibodies

PROTEIN BROWSER

CD8B-001	CD8B-002	CD8B-003	CD8B-004	CD8B-201	CD8B-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD8B-001 ENSP00000375070 ENST00000390655	P10966 [Direct mapping] T-cell surface glycoprotein CD8 beta chain Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0015026 [coreceptor activity] GO:0016032 [viral process] GO:0031901 [early endosome membrane] GO:0042101 [T cell receptor complex] GO:0042110 [T cell activation] GO:0042288 [MHC class I protein binding] GO:0050690 [regulation of defense response to virus by virus] GO:0050776 [regulation of immune response] Show all	210 aa 23.7 kDa	Yes	1
CD8B-002 ENSP00000331172 ENST00000331469	P10966 [Direct mapping] T-cell surface glycoprotein CD8 beta chain Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0015026 [coreceptor activity] GO:0016032 [viral process] GO:0031901 [early endosome membrane] GO:0042101 [T cell receptor complex] GO:0042110 [T cell activation] GO:0042288 [MHC class I protein binding] GO:0050690 [regulation of defense response to virus by virus] GO:0050776 [regulation of immune response] Show all	243 aa 27.2 kDa	Yes	1
CD8B-003 ENSP00000377356 ENST00000393759	P10966 [Direct mapping] T-cell surface glycoprotein CD8 beta chain Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0015026 [coreceptor activity] GO:0016032 [viral process] GO:0031901 [early endosome membrane] GO:0042101 [T cell receptor complex] GO:0042110 [T cell activation] GO:0042288 [MHC class I protein binding] GO:0050690 [regulation of defense response to virus by virus] GO:0050776 [regulation of immune response] Show all	221 aa 25 kDa	Yes	1
CD8B-004 ENSP00000340592 ENST00000349455	P10966 [Direct mapping] T-cell surface glycoprotein CD8 beta chain Show all	CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0015026 [coreceptor activity] GO:0016032 [viral process] GO:0031901 [early endosome membrane] GO:0042101 [T cell receptor complex] GO:0042110 [T cell activation] GO:0042288 [MHC class I protein binding] GO:0050690 [regulation of defense response to virus by virus] GO:0050776 [regulation of immune response] Show all	213 aa 24.3 kDa	Yes	0
CD8B-201 ENSP00000377358 ENST00000393761	P10966 [Direct mapping] T-cell surface glycoprotein CD8 beta chain Show all	CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0015026 [coreceptor activity] GO:0016032 [viral process] GO:0031901 [early endosome membrane] GO:0042101 [T cell receptor complex] GO:0042110 [T cell activation] GO:0042288 [MHC class I protein binding] GO:0050690 [regulation of defense response to virus by virus] GO:0050776 [regulation of immune response] Show all	198 aa 22.2 kDa	Yes	0
CD8B-202 ENSP00000394806 ENST00000431506	E9PD41 [Direct mapping] T-cell surface glycoprotein CD8 beta chain Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	210 aa 23.7 kDa	Yes	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.