Fields »
ABOUT
HELP
BLOG
CD8B

GENERAL INFORMATION

Gene name

 CD8B

Gene description

 CD8b molecule

Protein class

 CD markers
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cervix, uterine, lymph node)
GTEx:Tissue enhanced (spleen, small intestine)
FANTOM5:Tissue enhanced (lymph node)

Protein evidence

 Evidence at protein level

Protein expression

 High cytoplasmic expression in a subset of lymphoid cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
CAB004353
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cervix, uterine, lymph node)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node)

GENE INFORMATION

Gene name

 CD8B (HGNC Symbol)

Synonyms

 CD8B1

Description

 CD8b molecule (HGNC Symbol)

Entrez gene summary

 The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010]

Chromosome

 2

Cytoband

 p11.2

Chromosome location (bp)

 86815339 - 86861924

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172116 (version 83.38)

Entrez gene

 926

UniProt

 P10966 (UniProt - Evidence at transcript level)

neXtProt

 NX_P10966

Antibodypedia

 CD8B antibodies

PROTEIN BROWSER
CD8B-001
CD8B-002
CD8B-003
CD8B-004
CD8B-201
CD8B-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CD8B-001
ENSP00000375070
ENST00000390655
P10966 [Direct mapping]
T-cell surface glycoprotein CD8 beta chain
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0015026 [coreceptor activity]
GO:0016032 [viral process]
GO:0031901 [early endosome membrane]
GO:0042101 [T cell receptor complex]
GO:0042110 [T cell activation]
GO:0042288 [MHC class I protein binding]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050776 [regulation of immune response]
Show all
 210 aa
23.7 kDa 		Yes 1
CD8B-002
ENSP00000331172
ENST00000331469
P10966 [Direct mapping]
T-cell surface glycoprotein CD8 beta chain
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0015026 [coreceptor activity]
GO:0016032 [viral process]
GO:0031901 [early endosome membrane]
GO:0042101 [T cell receptor complex]
GO:0042110 [T cell activation]
GO:0042288 [MHC class I protein binding]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050776 [regulation of immune response]
Show all
 243 aa
27.2 kDa 		Yes 1
CD8B-003
ENSP00000377356
ENST00000393759
P10966 [Direct mapping]
T-cell surface glycoprotein CD8 beta chain
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0015026 [coreceptor activity]
GO:0016032 [viral process]
GO:0031901 [early endosome membrane]
GO:0042101 [T cell receptor complex]
GO:0042110 [T cell activation]
GO:0042288 [MHC class I protein binding]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050776 [regulation of immune response]
Show all
 221 aa
25 kDa 		Yes 1
CD8B-004
ENSP00000340592
ENST00000349455
P10966 [Direct mapping]
T-cell surface glycoprotein CD8 beta chain
Show all
CD markers
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0015026 [coreceptor activity]
GO:0016032 [viral process]
GO:0031901 [early endosome membrane]
GO:0042101 [T cell receptor complex]
GO:0042110 [T cell activation]
GO:0042288 [MHC class I protein binding]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050776 [regulation of immune response]
Show all
 213 aa
24.3 kDa 		Yes 0
CD8B-201
ENSP00000377358
ENST00000393761
P10966 [Direct mapping]
T-cell surface glycoprotein CD8 beta chain
Show all
CD markers
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0015026 [coreceptor activity]
GO:0016032 [viral process]
GO:0031901 [early endosome membrane]
GO:0042101 [T cell receptor complex]
GO:0042110 [T cell activation]
GO:0042288 [MHC class I protein binding]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050776 [regulation of immune response]
Show all
 198 aa
22.2 kDa 		Yes 0
CD8B-202
ENSP00000394806
ENST00000431506
E9PD41 [Direct mapping]
T-cell surface glycoprotein CD8 beta chain
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
Show all
 210 aa
23.7 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.