Cell atlas - MTBP - The Human Protein Atlas

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MTBP

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	MTBP
Gene description	MDM2 binding protein
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA050594
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus.

Main location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA050594	HEK 293	Nucleus
	HPA050594	HEK 293	Nuclear bodies	Intensity
	HPA050594	U-2 OS	Nucleus
	HPA050594	U-251 MG	Nucleus
			Nucleoli
			Cytosol

GENE INFORMATION
Gene name	MTBP
Synonyms
Description	MDM2 binding protein (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein regulates progression through the cell cycle and may be involved in tumor formation. [provided by RefSeq, Aug 2012]
Chromosome	8
Cytoband	q24.12
Chromosome location (bp)	120445400 - 120542133
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172167 (version 83.38)
Entrez gene	27085
UniProt	Q96DY7 (UniProt - Evidence at protein level)
neXtProt	NX_Q96DY7
Antibodypedia	MTBP antibodies

PROTEIN BROWSER

MTBP-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MTBP-001 ENSP00000303398 ENST00000305949	Q96DY7 [Direct mapping] Mdm2-binding protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000776 [kinetochore] GO:0000785 [chromatin] GO:0005515 [protein binding] GO:0007050 [cell cycle arrest] GO:0007089 [traversing start control point of mitotic cell cycle] GO:0008285 [negative regulation of cell proliferation] GO:0034501 [protein localization to kinetochore] GO:0045839 [negative regulation of mitotic nuclear division] Show all	904 aa 102.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.