Several cases of lymphomas, breast, colorectal, gastric and pancreatic cancers showed moderate cytoplasmic and/or membranous positivity. Nuclear staining was observed in a few cases. Remaining cancer tissues were in general weakly stained or negative.
CLEC7A (HGNC Symbol)
CD369, CLECSF12, dectin-1, hDectin-1
C-type lectin domain family 7, member A (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
Q68D78 [Direct mapping] C-type lectin domain family 7 member A; Putative uncharacterized protein DKFZp686L24211; cDNA FLJ59887, moderately similar to Homo sapiens C-type lectin domain family 7, member A (CLEC7A), transcript variant 4, mRNA