Expression of IL16 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Interleukin 16

Protein class

Cancer-related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA018467	CAB005247

GENE INFORMATION
Gene name	IL16 (HGNC Symbol)
Synonyms	FLJ16806, FLJ42735, HsT19289, IL-16, LCF, prIL-16
Description	Interleukin 16 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Chromosome	15
Cytoband	q25.1
Chromosome location (bp)	81159575 - 81314058
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172349 (version 83.38)
Entrez gene	3603
UniProt	Q14005 (UniProt - Evidence at protein level)
neXtProt	NX_Q14005
Antibodypedia	IL16 antibodies

PROTEIN BROWSER

IL16-001	IL16-002	IL16-003	IL16-005	IL16-006	IL16-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IL16-001 ENSP00000378155 ENST00000394660	Q14005 [Direct mapping] Pro-interleukin-16 Interleukin-16 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006955 [immune response] GO:0016032 [viral process] Show all	1331 aa 141.7 kDa	No	0
IL16-002 ENSP00000378147 ENST00000394652	Q14005 [Direct mapping] Pro-interleukin-16 Interleukin-16 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006955 [immune response] GO:0016032 [viral process] Show all	631 aa 66.6 kDa	No	0
IL16-003 ENSP00000302935 ENST00000302987	Q14005 [Direct mapping] Pro-interleukin-16 Interleukin-16 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005125 [cytokine activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006955 [immune response] GO:0016032 [viral process] GO:0030595 [leukocyte chemotaxis] GO:0050930 [induction of positive chemotaxis] Show all	1332 aa 141.8 kDa	No	0
IL16-005 ENSP00000453214 ENST00000558332	H0YLH9 [Direct mapping] Pro-interleukin-16 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005125 [cytokine activity] GO:0005515 [protein binding] Show all	611 aa 64.5 kDa	No	0
IL16-006 ENSP00000453250 ENST00000559383	H0YLL1 [Direct mapping] Pro-interleukin-16 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	594 aa 63.7 kDa	No	0
IL16-201 ENSP00000458125 ENST00000559388	Q14005 [Direct mapping] Pro-interleukin-16 Interleukin-16 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006955 [immune response] GO:0016032 [viral process] Show all	560 aa 59.3 kDa	No	0