Cell atlas - IL16 - The Human Protein Atlas

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IL16

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear speckles
	Plasma membrane

Human cell
	Cytosol
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	IL16
Gene description	Interleukin 16
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane, cytosol & nuclear speckles.
RNA cell category	Cell line enhanced (U-266/70, HMC-1, RPMI-8226, U-937, HEL)
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (approved), Plasma membrane (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA018467
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-266/70, HMC-1, RPMI-8226, U-937, HEL) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane, cytosol & nuclear speckles.

Main location

Nuclear speckles (approved), Plasma membrane (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA018467	A-431	Nuclear speckles
			Plasma membrane
			Cytosol
	HPA018467	U-2 OS	Nuclear speckles
			Plasma membrane
			Cytosol
	HPA018467	U-251 MG	Nuclear speckles
			Plasma membrane
			Cytosol

GENE INFORMATION
Gene name	IL16 (HGNC Symbol)
Synonyms	FLJ16806, FLJ42735, HsT19289, IL-16, LCF, prIL-16
Description	Interleukin 16 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Chromosome	15
Cytoband	q25.1
Chromosome location (bp)	81159575 - 81314058
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172349 (version 83.38)
Entrez gene	3603
UniProt	Q14005 (UniProt - Evidence at protein level)
neXtProt	NX_Q14005
Antibodypedia	IL16 antibodies

PROTEIN BROWSER

IL16-001	IL16-002	IL16-003	IL16-005	IL16-006	IL16-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IL16-001 ENSP00000378155 ENST00000394660	Q14005 [Direct mapping] Pro-interleukin-16 Interleukin-16 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006955 [immune response] GO:0016032 [viral process] Show all	1331 aa 141.7 kDa	No	0
IL16-002 ENSP00000378147 ENST00000394652	Q14005 [Direct mapping] Pro-interleukin-16 Interleukin-16 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006955 [immune response] GO:0016032 [viral process] Show all	631 aa 66.6 kDa	No	0
IL16-003 ENSP00000302935 ENST00000302987	Q14005 [Direct mapping] Pro-interleukin-16 Interleukin-16 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005125 [cytokine activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006955 [immune response] GO:0016032 [viral process] GO:0030595 [leukocyte chemotaxis] GO:0050930 [induction of positive chemotaxis] Show all	1332 aa 141.8 kDa	No	0
IL16-005 ENSP00000453214 ENST00000558332	H0YLH9 [Direct mapping] Pro-interleukin-16 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005125 [cytokine activity] GO:0005515 [protein binding] Show all	611 aa 64.5 kDa	No	0
IL16-006 ENSP00000453250 ENST00000559383	H0YLL1 [Direct mapping] Pro-interleukin-16 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	594 aa 63.7 kDa	No	0
IL16-201 ENSP00000458125 ENST00000559388	Q14005 [Direct mapping] Pro-interleukin-16 Interleukin-16 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006955 [immune response] GO:0016032 [viral process] Show all	560 aa 59.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.