Cell atlas - CFAP53 - The Human Protein Atlas

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CFAP53

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CELL CYCLE

GENE/PROTEIN

Antibody validation

Dictionary
	Midbody

Human cell
	Microtubules

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GENERAL INFORMATION
Gene name	CFAP53
Gene description	Cilia and flagella associated protein 53
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the midbody.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Midbody (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA041069
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the midbody.

Main location

Midbody (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA041069	A-431	No staining
	HPA041069	U-2 OS	Midbody	Intensity	Intensity
	HPA041069	U-251 MG	No staining

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition

GENE INFORMATION
Gene name	CFAP53 (HGNC Symbol)
Synonyms	CCDC11, FLJ32743
Description	Cilia and flagella associated protein 53 (HGNC Symbol)
Entrez gene summary	This gene belongs to the CFAP53 family. It was found to be differentially expressed by the ciliated cells of frog epidermis and in skin fibroblasts from human. Mutations in this gene are associated with visceral heterotaxy-6, which implicates this gene in determination of left-right asymmetric patterning. [provided by RefSeq, Aug 2015]
Chromosome	18
Cytoband	q21.1
Chromosome location (bp)	50227193 - 50266522
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172361 (version 83.38)
Entrez gene	220136
UniProt	Q96M91 (UniProt - Evidence at protein level)
neXtProt	NX_Q96M91
Antibodypedia	CFAP53 antibodies

PROTEIN BROWSER

CFAP53-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CFAP53-001 ENSP00000381553 ENST00000398545	Q96M91 [Direct mapping] Cilia- and flagella-associated protein 53 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005929 [cilium] GO:0008150 [biological_process] Show all	514 aa 61.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.