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ARNT2

CANCER ATLAS

Gene description

 Aryl-hydrocarbon receptor nuclear translocator 2

Protein class

 Disease related genes, Predicted intracellular proteins, Transcription factors

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA001056
CAB005081

GENE INFORMATION

Gene name

 ARNT2 (HGNC Symbol)

Synonyms

 bHLHe1, KIAA0307

Description

 Aryl-hydrocarbon receptor nuclear translocator 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting additional roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively. [provided by RefSeq, Dec 2013]

Chromosome

 15

Cytoband

 q25.1

Chromosome location (bp)

 80404350 - 80597937

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172379 (version 83.38)

Entrez gene

 9915

UniProt

 Q9HBZ2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HBZ2

Antibodypedia

 ARNT2 antibodies

PROTEIN BROWSER
ARNT2-001
ARNT2-004
ARNT2-006
ARNT2-007
ARNT2-201
ARNT2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARNT2-001
ENSP00000307479
ENST00000303329
Q9HBZ2 [Direct mapping]
Aryl hydrocarbon receptor nuclear translocator 2
X5DQN9 [Target identity:100%; Query identity:100%]
Aryl-hydrocarbon receptor nuclear translocator 2 isoform D
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001666 [response to hypoxia]
GO:0001701 [in utero embryonic development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007417 [central nervous system development]
GO:0007420 [brain development]
GO:0008284 [positive regulation of cell proliferation]
GO:0017162 [aryl hydrocarbon receptor binding]
GO:0032355 [response to estradiol]
GO:0043066 [negative regulation of apoptotic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
Show all
 717 aa
78.7 kDa 		No 0
ARNT2-004
ENSP00000453792
ENST00000527771
Q9HBZ2 [Direct mapping]
Aryl hydrocarbon receptor nuclear translocator 2
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Show all
GO:0001666 [response to hypoxia]
GO:0001701 [in utero embryonic development]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007417 [central nervous system development]
GO:0007420 [brain development]
GO:0017162 [aryl hydrocarbon receptor binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
Show all
 706 aa
77.6 kDa 		No 0
ARNT2-006
ENSP00000453651
ENST00000533983
Q9HBZ2 [Direct mapping]
Aryl hydrocarbon receptor nuclear translocator 2
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Show all
GO:0001666 [response to hypoxia]
GO:0001701 [in utero embryonic development]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007417 [central nervous system development]
GO:0007420 [brain development]
GO:0017162 [aryl hydrocarbon receptor binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
Show all
 706 aa
77.6 kDa 		No 0
ARNT2-007
ENSP00000452961
ENST00000525103
H0YKW1 [Direct mapping]
Aryl hydrocarbon receptor nuclear translocator 2
Show all
Predicted intracellular proteins
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 130 aa
14.4 kDa 		No 0
ARNT2-201
ENSP00000483762
ENST00000610490
Q7Z3A3 [Direct mapping]
Aryl hydrocarbon receptor nuclear translocator 2; Putative uncharacterized protein DKFZp686M216
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Predicted intracellular proteins
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
Show all
 566 aa
62.4 kDa 		No 0
ARNT2-202
ENSP00000479393
ENST00000622346
A0A087WVE9 [Direct mapping]
Aryl hydrocarbon receptor nuclear translocator 2
Show all
Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
Show all
 716 aa
79 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.