Expression of PDE3A in cancer - Summary

CANCER ATLAS

Gene description

Phosphodiesterase 3A, cGMP-inhibited

Protein class

Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA014492

GENE INFORMATION
Gene name	PDE3A (HGNC Symbol)
Synonyms	CGI-PDE
Description	Phosphodiesterase 3A, cGMP-inhibited (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Chromosome	12
Cytoband	p12.2
Chromosome location (bp)	20369245 - 20684381
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172572 (version 83.38)
Entrez gene	5139
UniProt	Q14432 (UniProt - Evidence at protein level)
neXtProt	NX_Q14432
Antibodypedia	PDE3A antibodies

PROTEIN BROWSER

PDE3A-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PDE3A-001 ENSP00000351957 ENST00000359062	Q14432 [Direct mapping] cGMP-inhibited 3',5'-cyclic phosphodiesterase A Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001556 [oocyte maturation] GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity] GO:0004119 [cGMP-inhibited cyclic-nucleotide phosphodiesterase activity] GO:0005829 [cytosol] GO:0006198 [cAMP catabolic process] GO:0006629 [lipid metabolic process] GO:0007165 [signal transduction] GO:0007596 [blood coagulation] GO:0008081 [phosphoric diester hydrolase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016101 [diterpenoid metabolic process] GO:0019933 [cAMP-mediated signaling] GO:0019934 [cGMP-mediated signaling] GO:0030552 [cAMP binding] GO:0040020 [regulation of meiotic nuclear division] GO:0042493 [response to drug] GO:0043066 [negative regulation of apoptotic process] GO:0043116 [negative regulation of vascular permeability] GO:0043117 [positive regulation of vascular permeability] GO:0046872 [metal ion binding] GO:0051591 [response to cAMP] GO:0060282 [positive regulation of oocyte development] GO:0071321 [cellular response to cGMP] GO:0071560 [cellular response to transforming growth factor beta stimulus] Show all	1141 aa 125 kDa	No	6