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PDE3A

GENERAL INFORMATION

Gene name

 PDE3A

Gene description

 Phosphodiesterase 3A, cGMP-inhibited

Protein class

 Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (heart muscle)
GTEx:Tissue enhanced (heart muscle)
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues, including blood vessels.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA014492
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (heart muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (heart muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PDE3A (HGNC Symbol)

Synonyms

 CGI-PDE

Description

 Phosphodiesterase 3A, cGMP-inhibited (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

Chromosome

 12

Cytoband

 p12.2

Chromosome location (bp)

 20369245 - 20684381

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172572 (version 83.38)

Entrez gene

 5139

UniProt

 Q14432 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14432

Antibodypedia

 PDE3A antibodies

PROTEIN BROWSER
PDE3A-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDE3A-001
ENSP00000351957
ENST00000359062
Q14432 [Direct mapping]
cGMP-inhibited 3',5'-cyclic phosphodiesterase A
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001556 [oocyte maturation]
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity]
GO:0004119 [cGMP-inhibited cyclic-nucleotide phosphodiesterase activity]
GO:0005829 [cytosol]
GO:0006198 [cAMP catabolic process]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016101 [diterpenoid metabolic process]
GO:0019933 [cAMP-mediated signaling]
GO:0019934 [cGMP-mediated signaling]
GO:0030552 [cAMP binding]
GO:0040020 [regulation of meiotic nuclear division]
GO:0042493 [response to drug]
GO:0043066 [negative regulation of apoptotic process]
GO:0043116 [negative regulation of vascular permeability]
GO:0043117 [positive regulation of vascular permeability]
GO:0046872 [metal ion binding]
GO:0051591 [response to cAMP]
GO:0060282 [positive regulation of oocyte development]
GO:0071321 [cellular response to cGMP]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
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 1141 aa
125 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.