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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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CCL19
  • premium

    TISSUE

  • CELL

  • CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CCL19

Gene description

Chemokine (C-C motif) ligand 19

Protein class

Cancer-related genes
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Group enriched (appendix, lymph node, tonsil, adipose tissue)
GTEx:Tissue enhanced (small intestine)
FANTOM5:Group enriched (lymph node, tonsil, appendix)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in immune cells.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
HPA067758
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Appendix

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (appendix, lymph node, tonsil, adipose tissue)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (lymph node, tonsil, appendix)

GENE INFORMATION

Gene name

CCL19 (HGNC Symbol)

Synonyms

CKb11, ELC, exodus-3, MIP-3b, SCYA19

Description

Chemokine (C-C motif) ligand 19 (HGNC Symbol)

Entrez gene summary

This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. [provided by RefSeq, Sep 2014]

Chromosome

9

Cytoband

p13.3

Chromosome location (bp)

34689567 - 34691277

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000172724 (version 83.38)

Entrez gene

6363

UniProt

Q99731 (UniProt - Evidence at protein level)

neXtProt

NX_Q99731

Antibodypedia

CCL19 antibodies

PROTEIN BROWSER

CCL19-001
CCL19-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CCL19-001
ENSP00000308815
ENST00000311925
Q99731 [Direct mapping]
C-C motif chemokine 19
Q6IBD6 [Target identity:100%; Query identity:100%]
C-C motif chemokine
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001768 [establishment of T cell polarity]
GO:0001771 [immunological synapse formation]
GO:0002407 [dendritic cell chemotaxis]
GO:0002408 [myeloid dendritic cell chemotaxis]
GO:0002548 [monocyte chemotaxis]
GO:0002606 [positive regulation of dendritic cell antigen processing and presentation]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005623 [cell]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007154 [cell communication]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007257 [activation of JUN kinase activity]
GO:0008009 [chemokine activity]
GO:0009615 [response to virus]
GO:0010560 [positive regulation of glycoprotein biosynthetic process]
GO:0031295 [T cell costimulation]
GO:0031732 [CCR7 chemokine receptor binding]
GO:0031735 [CCR10 chemokine receptor binding]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0034695 [response to prostaglandin E]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042346 [positive regulation of NF-kappaB import into nucleus]
GO:0042379 [chemokine receptor binding]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043547 [positive regulation of GTPase activity]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045627 [positive regulation of T-helper 1 cell differentiation]
GO:0045807 [positive regulation of endocytosis]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046330 [positive regulation of JNK cascade]
GO:0048020 [CCR chemokine receptor binding]
GO:0048247 [lymphocyte chemotaxis]
GO:0048260 [positive regulation of receptor-mediated endocytosis]
GO:0048469 [cell maturation]
GO:0050718 [positive regulation of interleukin-1 beta secretion]
GO:0050921 [positive regulation of chemotaxis]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060491 [regulation of cell projection assembly]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071346 [cellular response to interferon-gamma]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071731 [response to nitric oxide]
GO:0072610 [interleukin-12 secretion]
GO:0090023 [positive regulation of neutrophil chemotaxis]
GO:0097029 [mature conventional dendritic cell differentiation]
GO:0098586 [cellular response to virus]
GO:2000107 [negative regulation of leukocyte apoptotic process]
GO:2000147 [positive regulation of cell motility]
GO:2000549 [positive regulation of dendritic cell dendrite assembly]
Show all
98 aa
11 kDa
Yes 0
CCL19-003
ENSP00000368077
ENST00000378800
Q5VZ75 [Direct mapping]
C-C motif chemokine
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006955 [immune response]
GO:0008009 [chemokine activity]
GO:0060326 [cell chemotaxis]
Show all
104 aa
11.3 kDa
Yes 0

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