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CORO1B

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GENERAL INFORMATION

Gene name

 CORO1B

Gene description

 Coronin, actin binding protein, 1B

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane & cytosol.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (validated), Cytosol (validated)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
CAB017616 , HPA040113
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane & cytosol.

Main location

 Plasma membrane (validated), Cytosol (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB017616 A-431 Plasma membrane
Cytosol
CAB017616 U-2 OS Plasma membrane
Cytosol
CAB017616 U-251 MG Plasma membrane
Cytosol
HPA040113 A-431 Plasma membrane
Cytosol
HPA040113 MCF7 Plasma membrane
Cytosol
HPA040113 U-2 OS Plasma membrane
Cytosol

GENE INFORMATION

Gene name

 CORO1B (HGNC Symbol)

Synonyms

 coronin-2

Description

 Coronin, actin binding protein, 1B (HGNC Symbol)

Entrez gene summary

 Members of the coronin family, such as CORO1B, are WD repeat-containing actin-binding proteins that regulate cell motility (Cai et al., 2005 [PubMed 16027158]).[supplied by OMIM, Mar 2008]

Chromosome

 11

Cytoband

 q13.2

Chromosome location (bp)

 67435510 - 67443821

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172725 (version 83.38)

Entrez gene

 57175

UniProt

 Q9BR76 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BR76

Antibodypedia

 CORO1B antibodies

PROTEIN BROWSER
CORO1B-001
CORO1B-008
CORO1B-201
CORO1B-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CORO1B-001
ENSP00000340211
ENST00000341356
Q9BR76 [Direct mapping]
Coronin-1B
A0A024R5K1 [Target identity:100%; Query identity:100%]
Coronin
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0030027 [lamellipodium]
GO:0030036 [actin cytoskeleton organization]
GO:0031252 [cell leading edge]
GO:0031529 [ruffle organization]
GO:0034315 [regulation of Arp2/3 complex-mediated actin nucleation]
GO:0034316 [negative regulation of Arp2/3 complex-mediated actin nucleation]
GO:0035767 [endothelial cell chemotaxis]
GO:0036120 [cellular response to platelet-derived growth factor stimulus]
GO:0042060 [wound healing]
GO:0042802 [identical protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
GO:0070062 [extracellular exosome]
GO:0071672 [negative regulation of smooth muscle cell chemotaxis]
GO:0071933 [Arp2/3 complex binding]
GO:0071944 [cell periphery]
GO:0090135 [actin filament branching]
GO:1902463 [protein localization to cell leading edge]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
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 489 aa
54.2 kDa 		No 0
CORO1B-008
ENSP00000438056
ENST00000545016
F5H0D2 [Direct mapping]
Coronin
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0015629 [actin cytoskeleton]
GO:0030036 [actin cytoskeleton organization]
GO:0051015 [actin filament binding]
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 139 aa
15.3 kDa 		No 0
CORO1B-201
ENSP00000377471
ENST00000393893
Q9BR76 [Direct mapping]
Coronin-1B
A0A024R5K1 [Target identity:100%; Query identity:100%]
Coronin
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0030027 [lamellipodium]
GO:0030036 [actin cytoskeleton organization]
GO:0031252 [cell leading edge]
GO:0031529 [ruffle organization]
GO:0034315 [regulation of Arp2/3 complex-mediated actin nucleation]
GO:0034316 [negative regulation of Arp2/3 complex-mediated actin nucleation]
GO:0035767 [endothelial cell chemotaxis]
GO:0036120 [cellular response to platelet-derived growth factor stimulus]
GO:0042060 [wound healing]
GO:0042802 [identical protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
GO:0070062 [extracellular exosome]
GO:0071672 [negative regulation of smooth muscle cell chemotaxis]
GO:0071933 [Arp2/3 complex binding]
GO:0071944 [cell periphery]
GO:0090135 [actin filament branching]
GO:1902463 [protein localization to cell leading edge]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
Show all
 489 aa
54.2 kDa 		No 0
CORO1B-202
ENSP00000486585
ENST00000627576
F5H390 [Direct mapping]
Coronin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0015629 [actin cytoskeleton]
Show all
 282 aa
31 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.