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DCP2

CANCER ATLAS

Gene description

 Decapping mRNA 2

Protein class

 Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB011677

Tissue

Cancer staining

Protein
expression of
normal tissue
Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue
Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

 Malignant cells showed weak to moderate cytoplasmic positivity.

GENE INFORMATION

Gene name

 DCP2 (HGNC Symbol)

Synonyms

 NUDT20

Description

 Decapping mRNA 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

Chromosome

 5

Cytoband

 q22.2

Chromosome location (bp)

 112976702 - 113020970

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172795 (version 83.38)

Entrez gene

 167227

UniProt

 Q8IU60 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IU60

Antibodypedia

 DCP2 antibodies

PROTEIN BROWSER
DCP2-001
DCP2-002
DCP2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DCP2-001
ENSP00000373715
ENST00000389063
Q8IU60 [Direct mapping]
m7GpppN-mRNA hydrolase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000290 [deadenylation-dependent decapping of nuclear-transcribed mRNA]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006402 [mRNA catabolic process]
GO:0010467 [gene expression]
GO:0016442 [RISC complex]
GO:0016787 [hydrolase activity]
GO:0016896 [exoribonuclease activity, producing 5'-phosphomonoesters]
GO:0030054 [cell junction]
GO:0030145 [manganese ion binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043488 [regulation of mRNA stability]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0050072 [m7G(5')pppN diphosphatase activity]
GO:0071044 [histone mRNA catabolic process]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
Show all
 420 aa
48.4 kDa 		No 0
DCP2-002
ENSP00000425770
ENST00000515408
Q8IU60 [Direct mapping]
m7GpppN-mRNA hydrolase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000290 [deadenylation-dependent decapping of nuclear-transcribed mRNA]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006402 [mRNA catabolic process]
GO:0010467 [gene expression]
GO:0016442 [RISC complex]
GO:0016787 [hydrolase activity]
GO:0016896 [exoribonuclease activity, producing 5'-phosphomonoesters]
GO:0030054 [cell junction]
GO:0030145 [manganese ion binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043488 [regulation of mRNA stability]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0050072 [m7G(5')pppN diphosphatase activity]
GO:0071044 [histone mRNA catabolic process]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
Show all
 385 aa
44.4 kDa 		No 0
DCP2-003
ENSP00000424982
ENST00000513585
H0Y9T5 [Direct mapping]
m7GpppN-mRNA hydrolase
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
Show all
 402 aa
44.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.