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DCP2

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GENERAL INFORMATION

Gene name

 DCP2

Gene description

 Decapping mRNA 2

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm & cytoplasmic bodies. In addition localized to the cell junctions.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (approved), Cytoplasmic bodies (approved)

Additional location

 In addition localized to the Cell Junctions (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA057676
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm & cytoplasmic bodies. In addition localized to the cell junctions.

Main location

 Nucleoplasm (approved), Cytoplasmic bodies (approved)

Additional location

 Cell Junctions (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA057676 CACO-2 Nucleoplasm
Cell Junctions
Cytoplasmic bodies
HPA057676 MCF7 Nucleoplasm
Cell Junctions
Cytoplasmic bodies
HPA057676 U-2 OS Nucleoplasm
Cytoplasmic bodies

GENE INFORMATION

Gene name

 DCP2 (HGNC Symbol)

Synonyms

 NUDT20

Description

 Decapping mRNA 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

Chromosome

 5

Cytoband

 q22.2

Chromosome location (bp)

 112976702 - 113020970

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172795 (version 83.38)

Entrez gene

 167227

UniProt

 Q8IU60 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IU60

Antibodypedia

 DCP2 antibodies

PROTEIN BROWSER
DCP2-001
DCP2-002
DCP2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DCP2-001
ENSP00000373715
ENST00000389063
Q8IU60 [Direct mapping]
m7GpppN-mRNA hydrolase
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000290 [deadenylation-dependent decapping of nuclear-transcribed mRNA]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006402 [mRNA catabolic process]
GO:0010467 [gene expression]
GO:0016442 [RISC complex]
GO:0016787 [hydrolase activity]
GO:0016896 [exoribonuclease activity, producing 5'-phosphomonoesters]
GO:0030054 [cell junction]
GO:0030145 [manganese ion binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043488 [regulation of mRNA stability]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0050072 [m7G(5')pppN diphosphatase activity]
GO:0071044 [histone mRNA catabolic process]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
Show all
 420 aa
48.4 kDa 		No 0
DCP2-002
ENSP00000425770
ENST00000515408
Q8IU60 [Direct mapping]
m7GpppN-mRNA hydrolase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000290 [deadenylation-dependent decapping of nuclear-transcribed mRNA]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006402 [mRNA catabolic process]
GO:0010467 [gene expression]
GO:0016442 [RISC complex]
GO:0016787 [hydrolase activity]
GO:0016896 [exoribonuclease activity, producing 5'-phosphomonoesters]
GO:0030054 [cell junction]
GO:0030145 [manganese ion binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043488 [regulation of mRNA stability]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0050072 [m7G(5')pppN diphosphatase activity]
GO:0071044 [histone mRNA catabolic process]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
Show all
 385 aa
44.4 kDa 		No 0
DCP2-003
ENSP00000424982
ENST00000513585
H0Y9T5 [Direct mapping]
m7GpppN-mRNA hydrolase
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
Show all
 402 aa
44.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.