Expression of CYP7B1 in cancer - Summary

CANCER ATLAS

Gene description

Cytochrome P450, family 7, subfamily B, polypeptide 1

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA017761

GENE INFORMATION
Gene name	CYP7B1 (HGNC Symbol)
Synonyms	SPG5A
Description	Cytochrome P450, family 7, subfamily B, polypeptide 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	q12.3
Chromosome location (bp)	64587763 - 64798761
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172817 (version 83.38)
Entrez gene	9420
UniProt	O75881 (UniProt - Evidence at protein level)
neXtProt	NX_O75881
Antibodypedia	CYP7B1 antibodies

PROTEIN BROWSER

CYP7B1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CYP7B1-001 ENSP00000310721 ENST00000310193	O75881 [Direct mapping] 25-hydroxycholesterol 7-alpha-hydroxylase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005506 [iron ion binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006699 [bile acid biosynthetic process] GO:0006805 [xenobiotic metabolic process] GO:0008203 [cholesterol metabolic process] GO:0008206 [bile acid metabolic process] GO:0008396 [oxysterol 7-alpha-hydroxylase activity] GO:0016125 [sterol metabolic process] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0033147 [negative regulation of intracellular estrogen receptor signaling pathway] GO:0033783 [25-hydroxycholesterol 7alpha-hydroxylase activity] GO:0044281 [small molecule metabolic process] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0055114 [oxidation-reduction process] GO:0060740 [prostate gland epithelium morphogenesis] Show all	506 aa 58.3 kDa	No	2