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CYP7B1

GENERAL INFORMATION

Gene name

 CYP7B1

Gene description

 Cytochrome P450, family 7, subfamily B, polypeptide 1

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (parathyroid gland)
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear staining in most tissues.

DATA RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA017761
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (parathyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CYP7B1 (HGNC Symbol)

Synonyms

 SPG5A

Description

 Cytochrome P450, family 7, subfamily B, polypeptide 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 q12.3

Chromosome location (bp)

 64587763 - 64798761

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172817 (version 83.38)

Entrez gene

 9420

UniProt

 O75881 (UniProt - Evidence at protein level)

neXtProt

 NX_O75881

Antibodypedia

 CYP7B1 antibodies

PROTEIN BROWSER
CYP7B1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CYP7B1-001
ENSP00000310721
ENST00000310193
O75881 [Direct mapping]
25-hydroxycholesterol 7-alpha-hydroxylase
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005506 [iron ion binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006699 [bile acid biosynthetic process]
GO:0006805 [xenobiotic metabolic process]
GO:0008203 [cholesterol metabolic process]
GO:0008206 [bile acid metabolic process]
GO:0008396 [oxysterol 7-alpha-hydroxylase activity]
GO:0016125 [sterol metabolic process]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0020037 [heme binding]
GO:0033147 [negative regulation of intracellular estrogen receptor signaling pathway]
GO:0033783 [25-hydroxycholesterol 7alpha-hydroxylase activity]
GO:0044281 [small molecule metabolic process]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0055114 [oxidation-reduction process]
GO:0060740 [prostate gland epithelium morphogenesis]
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 506 aa
58.3 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.