Cell atlas - METAP1D - The Human Protein Atlas

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METAP1D

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	METAP1D
Gene description	Methionyl aminopeptidase type 1D (mitochondrial)
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA030298 , HPA030299
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA030298	HEK 293	No staining
HPA030298	Hep G2	Vesicles
HPA030298	U-2 OS	No staining
HPA030299	A-431	Vesicles
HPA030299	U-2 OS	Vesicles
HPA030299	U-251 MG	Vesicles

MOUSE CELLS

Main location

Not available

Mouse gene

ENSMUSG00000041921 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA030298	NIH 3T3	No staining

GENE INFORMATION
Gene name	METAP1D (HGNC Symbol)
Synonyms	MAP1D, Metap1l
Description	Methionyl aminopeptidase type 1D (mitochondrial) (HGNC Symbol)
Entrez gene summary	The N-terminal methionine excision pathway is an essential process in which the N-terminal methionine is removed from many proteins, thus facilitating subsequent protein modification. In mitochondria, enzymes that catalyze this reaction are celled methionine aminopeptidases (MetAps, or MAPs; EC 3.4.11.18) (Serero et al., 2003 [PubMed 14532271]).[supplied by OMIM, Mar 2008]
Chromosome	2
Cytoband	q31.1
Chromosome location (bp)	171999583 - 172082430
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172878 (version 83.38)
Entrez gene	254042
UniProt	Q6UB28 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UB28
Antibodypedia	METAP1D antibodies

PROTEIN BROWSER

METAP1D-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
METAP1D-001 ENSP00000315152 ENST00000315796	Q6UB28 [Direct mapping] Methionine aminopeptidase 1D, mitochondrial Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004177 [aminopeptidase activity] GO:0005739 [mitochondrion] GO:0006508 [proteolysis] GO:0008235 [metalloexopeptidase activity] GO:0018206 [peptidyl-methionine modification] GO:0031365 [N-terminal protein amino acid modification] GO:0046872 [metal ion binding] Show all	335 aa 37.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.