We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
A majority of malignant cells displayed moderate to strong cytoplasmic immunoreactivity. Several malignant gliomas, renal cancers and liver cancers were weakly stained or negative.
Most malignant cells showed moderate to strong cytoplasmic immunoreactivity.
GENE INFORMATION
Gene name
RELA (HGNC Symbol)
Synonyms
NFKB3, p65
Description
V-rel avian reticuloendotheliosis viral oncogene homolog A (HGNC Symbol)
Entrez gene summary
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Predicted intracellular proteins Transcription factors Immunoglobulin fold RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0001889 [liver development] GO:0001942 [hair follicle development] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006117 [acetaldehyde metabolic process] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006952 [defense response] GO:0006954 [inflammatory response] GO:0006968 [cellular defense response] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0007568 [aging] GO:0008134 [transcription factor binding] GO:0008284 [positive regulation of cell proliferation] GO:0009612 [response to mechanical stimulus] GO:0009617 [response to bacterium] GO:0009887 [organ morphogenesis] GO:0010033 [response to organic substance] GO:0010035 [response to inorganic substance] GO:0010224 [response to UV-B] GO:0014040 [positive regulation of Schwann cell differentiation] GO:0014070 [response to organic cyclic compound] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0031293 [membrane protein intracellular domain proteolysis] GO:0031490 [chromatin DNA binding] GO:0031625 [ubiquitin protein ligase binding] GO:0032332 [positive regulation of chondrocyte differentiation] GO:0032403 [protein complex binding] GO:0032481 [positive regulation of type I interferon production] GO:0032495 [response to muramyl dipeptide] GO:0032496 [response to lipopolysaccharide] GO:0032570 [response to progesterone] GO:0032868 [response to insulin] GO:0033256 [I-kappaB/NF-kappaB complex] GO:0033590 [response to cobalamin] GO:0033613 [activating transcription factor binding] GO:0034097 [response to cytokine] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0035994 [response to muscle stretch] GO:0038061 [NIK/NF-kappaB signaling] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0042177 [negative regulation of protein catabolic process] GO:0042301 [phosphate ion binding] GO:0042493 [response to drug] GO:0042542 [response to hydrogen peroxide] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042805 [actinin binding] GO:0042826 [histone deacetylase binding] GO:0043066 [negative regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043200 [response to amino acid] GO:0043234 [protein complex] GO:0043278 [response to morphine] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045084 [positive regulation of interleukin-12 biosynthetic process] GO:0045087 [innate immune response] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046627 [negative regulation of insulin receptor signaling pathway] GO:0046982 [protein heterodimerization activity] GO:0047485 [protein N-terminus binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050727 [regulation of inflammatory response] GO:0050852 [T cell receptor signaling pathway] GO:0051059 [NF-kappaB binding] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051591 [response to cAMP] GO:0051607 [defense response to virus] GO:0070301 [cellular response to hydrogen peroxide] GO:0070431 [nucleotide-binding oligomerization domain containing 2 signaling pathway] GO:0070491 [repressing transcription factor binding] GO:0070555 [response to interleukin-1] GO:0071159 [NF-kappaB complex] GO:0071222 [cellular response to lipopolysaccharide] GO:0071316 [cellular response to nicotine] GO:0071347 [cellular response to interleukin-1] GO:0071354 [cellular response to interleukin-6] GO:0071356 [cellular response to tumor necrosis factor] GO:0071375 [cellular response to peptide hormone stimulus] GO:0071532 [ankyrin repeat binding] GO:1901223 [negative regulation of NIK/NF-kappaB signaling] GO:2000630 [positive regulation of miRNA metabolic process] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Predicted intracellular proteins Transcription factors Immunoglobulin fold RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006954 [inflammatory response] GO:0006968 [cellular defense response] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0008134 [transcription factor binding] GO:0008284 [positive regulation of cell proliferation] GO:0010033 [response to organic substance] GO:0010224 [response to UV-B] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0019901 [protein kinase binding] GO:0031293 [membrane protein intracellular domain proteolysis] GO:0031490 [chromatin DNA binding] GO:0031625 [ubiquitin protein ligase binding] GO:0032481 [positive regulation of type I interferon production] GO:0033256 [I-kappaB/NF-kappaB complex] GO:0033613 [activating transcription factor binding] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0038061 [NIK/NF-kappaB signaling] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0042301 [phosphate ion binding] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042805 [actinin binding] GO:0042826 [histone deacetylase binding] GO:0043066 [negative regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0044212 [transcription regulatory region DNA binding] GO:0045087 [innate immune response] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0047485 [protein N-terminus binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050727 [regulation of inflammatory response] GO:0050852 [T cell receptor signaling pathway] GO:0051059 [NF-kappaB binding] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051607 [defense response to virus] GO:0070301 [cellular response to hydrogen peroxide] GO:0070431 [nucleotide-binding oligomerization domain containing 2 signaling pathway] GO:0070491 [repressing transcription factor binding] GO:0070555 [response to interleukin-1] GO:0071159 [NF-kappaB complex] GO:0071316 [cellular response to nicotine] GO:0071347 [cellular response to interleukin-1] GO:0071354 [cellular response to interleukin-6] GO:0071356 [cellular response to tumor necrosis factor] GO:0071375 [cellular response to peptide hormone stimulus] GO:1901223 [negative regulation of NIK/NF-kappaB signaling] GO:2000630 [positive regulation of miRNA metabolic process] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]