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V-rel avian reticuloendotheliosis viral oncogene homolog A (HGNC Symbol)
Entrez gene summary
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Predicted intracellular proteins Transcription factors Immunoglobulin fold RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0001889 [liver development] GO:0001942 [hair follicle development] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006117 [acetaldehyde metabolic process] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006952 [defense response] GO:0006954 [inflammatory response] GO:0006968 [cellular defense response] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0007568 [aging] GO:0008134 [transcription factor binding] GO:0008284 [positive regulation of cell proliferation] GO:0009612 [response to mechanical stimulus] GO:0009617 [response to bacterium] GO:0009887 [organ morphogenesis] GO:0010033 [response to organic substance] GO:0010035 [response to inorganic substance] GO:0010224 [response to UV-B] GO:0014040 [positive regulation of Schwann cell differentiation] GO:0014070 [response to organic cyclic compound] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0031293 [membrane protein intracellular domain proteolysis] GO:0031490 [chromatin DNA binding] GO:0031625 [ubiquitin protein ligase binding] GO:0032332 [positive regulation of chondrocyte differentiation] GO:0032403 [protein complex binding] GO:0032481 [positive regulation of type I interferon production] GO:0032495 [response to muramyl dipeptide] GO:0032496 [response to lipopolysaccharide] GO:0032570 [response to progesterone] GO:0032868 [response to insulin] GO:0033256 [I-kappaB/NF-kappaB complex] GO:0033590 [response to cobalamin] GO:0033613 [activating transcription factor binding] GO:0034097 [response to cytokine] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0035994 [response to muscle stretch] GO:0038061 [NIK/NF-kappaB signaling] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0042177 [negative regulation of protein catabolic process] GO:0042301 [phosphate ion binding] GO:0042493 [response to drug] GO:0042542 [response to hydrogen peroxide] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042805 [actinin binding] GO:0042826 [histone deacetylase binding] GO:0043066 [negative regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043200 [response to amino acid] GO:0043234 [protein complex] GO:0043278 [response to morphine] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045084 [positive regulation of interleukin-12 biosynthetic process] GO:0045087 [innate immune response] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046627 [negative regulation of insulin receptor signaling pathway] GO:0046982 [protein heterodimerization activity] GO:0047485 [protein N-terminus binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050727 [regulation of inflammatory response] GO:0050852 [T cell receptor signaling pathway] GO:0051059 [NF-kappaB binding] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051591 [response to cAMP] GO:0051607 [defense response to virus] GO:0070301 [cellular response to hydrogen peroxide] GO:0070431 [nucleotide-binding oligomerization domain containing 2 signaling pathway] GO:0070491 [repressing transcription factor binding] GO:0070555 [response to interleukin-1] GO:0071159 [NF-kappaB complex] GO:0071222 [cellular response to lipopolysaccharide] GO:0071316 [cellular response to nicotine] GO:0071347 [cellular response to interleukin-1] GO:0071354 [cellular response to interleukin-6] GO:0071356 [cellular response to tumor necrosis factor] GO:0071375 [cellular response to peptide hormone stimulus] GO:0071532 [ankyrin repeat binding] GO:1901223 [negative regulation of NIK/NF-kappaB signaling] GO:2000630 [positive regulation of miRNA metabolic process] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Predicted intracellular proteins Transcription factors Immunoglobulin fold RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006954 [inflammatory response] GO:0006968 [cellular defense response] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0008134 [transcription factor binding] GO:0008284 [positive regulation of cell proliferation] GO:0010033 [response to organic substance] GO:0010224 [response to UV-B] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0019901 [protein kinase binding] GO:0031293 [membrane protein intracellular domain proteolysis] GO:0031490 [chromatin DNA binding] GO:0031625 [ubiquitin protein ligase binding] GO:0032481 [positive regulation of type I interferon production] GO:0033256 [I-kappaB/NF-kappaB complex] GO:0033613 [activating transcription factor binding] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0038061 [NIK/NF-kappaB signaling] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0042301 [phosphate ion binding] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042805 [actinin binding] GO:0042826 [histone deacetylase binding] GO:0043066 [negative regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0044212 [transcription regulatory region DNA binding] GO:0045087 [innate immune response] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0047485 [protein N-terminus binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050727 [regulation of inflammatory response] GO:0050852 [T cell receptor signaling pathway] GO:0051059 [NF-kappaB binding] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051607 [defense response to virus] GO:0070301 [cellular response to hydrogen peroxide] GO:0070431 [nucleotide-binding oligomerization domain containing 2 signaling pathway] GO:0070491 [repressing transcription factor binding] GO:0070555 [response to interleukin-1] GO:0071159 [NF-kappaB complex] GO:0071316 [cellular response to nicotine] GO:0071347 [cellular response to interleukin-1] GO:0071354 [cellular response to interleukin-6] GO:0071356 [cellular response to tumor necrosis factor] GO:0071375 [cellular response to peptide hormone stimulus] GO:1901223 [negative regulation of NIK/NF-kappaB signaling] GO:2000630 [positive regulation of miRNA metabolic process] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]